ORBi: Colinet Frédéric - Mapping and polymorphism of bovine ghreline gene

Reference : Mapping and polymorphism of bovine ghreline gene


	Document type :	Scientific congresses and symposiums : Poster
	Discipline(s) :	Life sciences : Genetics & genetic processes Life sciences : Animal production & animal husbandry
	To cite this reference:	http://hdl.handle.net/2268/70275

Title :	Mapping and polymorphism of bovine ghreline gene
Language :	English
Author, co-author :	Colinet, Frédéric [Faculté Universitaire des Sciences Agronomiques de Gembloux - FUSAGx > > Biologie animale et microbienne > >]
	Eggen, André [Institut Scientifique de Recherche Agronomique - INRA > > Laboratoire de Génétique Biochimique et Cytogénétique (LGBC - UR339) > >]
	Halleux, Caroline [Faculté Universitaire des Sciences Agronomiques de Gembloux - FUSAGx > > Biologie animale et microbienne > >]
	Arnould, Valérie [Faculté Universitaire des Sciences Agronomiques de Gembloux - FUSAGx > > Biologie animale et microbienne > >]
	Portetelle, Daniel [Université de Liège - ULg > Chimie et bio-industries > Biologie animale et microbienne >]
	Renaville, Robert [Université de Liège - ULg > Chimie et bio-industries > Biologie animale et microbienne >]
Publication date :	Aug-2006
Page number :	A0
On invitation :	No
Audience :	International
Event name :	30th Conference of the International Society of Animal Genetics
Event date :	du 20 août 2006 au 25 août 2006
Event organizer :	Colégio Brasileiro de Reprodução Animal
Event place (city) :	Porto Seguro
Event country :	Brésil
Keywords :	[en] Ghrelin ; Mapping ; Polymorphism
Abstract :	[en] Bovine ghrelin, a 27-amino-acid peptide has been identified in bovine oxyntic glands of the abomasum. It is an endogenous growth hormone secretagogue. Total mRNA was extracted from abomasum and complete ghrelin mRNA was sequenced by rapid amplification of cDNA ends. The gene contains five exons and four introns with a short noncoding first exon of 17 bp similar to mouse and human ghrelin gene. Using a radiation hybrid panel, the gene was mapped to chromosome 22 near microsatellite markers UWCA49, BM4102, BMS1932, BM2613 and URB035 with good LOD Score. Some studies detected different QTLs near these markers like for milk fat percent, milk protein percent and somatic cell score. So, it would be interesting to study the polymorphism on the bovine ghrelin gene. Screening for polymorphisms in the five exons and the introns II and IV on ten Belgian Blue bulls, ten Holsteins bulls and ten Limousin bulls revealed a total of three single nucleotide polymorphisms. In order to evaluate if ghrelin could be involved in genetic variation for milk fat percent, milk protein percent and somatic cell score an association study between SNPs on ghrelin gene and these traits could be performed in a major cattle population.
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/70275

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