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| Reference : C-60-containing nanostructured polymeric materials with potential biomedical applications |
| Scientific journals : Article | |||
| Engineering, computing & technology : Materials science & engineering Physical, chemical, mathematical & earth Sciences : Chemistry | |||
| http://hdl.handle.net/2268/7014 | |||
| C-60-containing nanostructured polymeric materials with potential biomedical applications | |
| English | |
| Stoilova, Olya [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >] | |
Jérôme, Christine  [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >] | |
| Detrembleur, Christophe [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >] | |
| Mouithys-Mickalad, Ange [University of Liège (ULg) > > Center for Oxygen R&D (CORD) > >] | |
| Manolova, Nevena [Institute of Polymers, Bulgarian Academy of Sciences, Sofia, Bulgaria > > Laboratory of Bioactive Polymers > >] | |
| Rashkov, Iliya [Institute of Polymers, Bulgarian Academy of Sciences, Sofia, Bulgaria > > Laboratory of Bioactive Polymers > >] | |
| Jérôme, Robert [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >] | |
| 23-Mar-2007 | |
| Polymer | |
| Elsevier Sci Ltd | |
| 48 | |
| 7 | |
| 1835-1843 | |
| International | |
| 0032-3861 | |
| Oxford | |
| [en] carbon fullerene ; biomaterial ; nanomedicine ; electrospinning ; fiber | |
| [en] Star-shaped polymers with a fullerene (C-60) Core and an unexpanded structure were successfully prepared by reaction Of C60 with amino end-capped polyesters HxC60(NHPCLn)(x) and polyethers HxC60(NHPEG(n))(x), respectively. Upon irradiation of these C-60-derivatives, a large amount of singlet oxygen was released. Compared to previously synthesized star-shaped azafulleroids with an expanded structure, the photosensitivity of HxC60(NHPCLn)(x) is higher as assessed by a higher production of singlet oxygen. The cytotoxicity of the photoactive water-soluble HxC60(NHPEG(n))(x) derivatives was tested against THP-1 cells and expressed in terms of cell viability. Moreover, they were processed as micro-/nanosized fibers by electrospinning, which however required the addition of poly(F-caprolactone) (PCL). The diameter distribution of the fibers was trimodal, where the fraction with the 270 nm average diameter was the major population. Because of their photoactivity, the herein reported star-shaped C-60-derivatives are promising candidates for photodynamic cancer therapy and treatment of multidrug resistant pathogens. (c) 2007 Elsevier Ltd. All rights reserved. | |
| Center for Education and Research on Macromolecules (CERM) | |
| Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; The University of Liège ; The Bulgarian National Science Fund, Grant NANOBIOMAT, NT 4-01/04 ; The CGRI ; The Bulgarian Academy of Sciences | |
| Researchers | |
| http://hdl.handle.net/2268/7014 | |
| 10.1016/j.polymer.2007.02.026 | |
| http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TXW-4N2D2VW-5-Y&_cdi=5601&_user=532038&_orig=browse&_coverDate=03%2F23%2F2007&_sk=999519992&view=c&wchp=dGLzVzz-zSkWA&md5=a65cd810bb2d726ff6ba908770911262&ie=/sdarticle.pdf | |
| http://www.elsevier.com/wps/find/journaldescription.cws_home/30466/description#description | |
| The authors acknowledge Polymer (Elsevier) for allowing them to archive this paper. |
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