[en] Star-shaped polymers with a fullerene (C-60) Core and an unexpanded structure were successfully prepared by reaction Of C60 with amino end-capped polyesters HxC60(NHPCLn)(x) and polyethers HxC60(NHPEG(n))(x), respectively. Upon irradiation of these C-60-derivatives, a large amount of singlet oxygen was released. Compared to previously synthesized star-shaped azafulleroids with an expanded structure, the photosensitivity of HxC60(NHPCLn)(x) is higher as assessed by a higher production of singlet oxygen. The cytotoxicity of the photoactive water-soluble HxC60(NHPEG(n))(x) derivatives was tested against THP-1 cells and expressed in terms of cell viability. Moreover, they were processed as micro-/nanosized fibers by electrospinning, which however required the addition of poly(F-caprolactone) (PCL). The diameter distribution of the fibers was trimodal, where the fraction with the 270 nm average diameter was the major population. Because of their photoactivity, the herein reported star-shaped C-60-derivatives are promising candidates for photodynamic cancer therapy and treatment of multidrug resistant pathogens. (c) 2007 Elsevier Ltd. All rights reserved.
Center for Education and Research on Macromolecules (CERM)
Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; The University of Liège ; The Bulgarian National Science Fund, Grant NANOBIOMAT, NT 4-01/04 ; The CGRI ; The Bulgarian Academy of Sciences