Reference : Oral calcitonin in the management of osteoarthritis: hope or fantasy ?
Scientific journals : Article
Human health sciences : General & internal medicine
http://hdl.handle.net/2268/70119
Oral calcitonin in the management of osteoarthritis: hope or fantasy ?
English
Reginster, Jean-Yves mailto [Université de Liège - ULg > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé >]
Neuprez, Audrey [Université de Liège - ULg > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé >]
Hiligsmann, Mickaël mailto [Université de Liège - ULg > Département des sciences de la santé publique > Département des sciences de la santé publique >]
Bruyère, Olivier mailto [Université de Liège - ULg > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé >]
Feb-2010
International Journal of Clinical Rheumatology
Future Medicine Ltd
5
1
53-58
Yes (verified by ORBi)
International
1758-4272
1758-4280
In the mid-1980s, calcitonin was used as a potential treatment for postmenopausal osteoporosis. However, after the results obtained in a pivotal study assessing the antifracture efficacy of the drug showed an absence of reduction in nonvertebral fractures, calcitonin has almost completely disappeared from the osteoporosis armomentarium. The development of a new ‘high-tech’ oral formulation of salmon calcitonin and the demonstration, in several in vitro and in vivo models of osteoarthritis, that this drug could exert beneficial effects on the chondrocytes and on the development of experimental osteoarthritis has generated some interest in this old molecule. However, at this stage, results from clinical trials remain inconclusive and caution should be exerted before considering oral calcitonin as a breakthrough in the management of osteoarthritis.
http://hdl.handle.net/2268/70119
also: http://hdl.handle.net/2268/92853
10.2217/ijr.09.68

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