ORBi: Keller Matthieu - The alpha-fetoprotein knock-out mouse model suggests that parental behavior is sexually differentiated under the influence of prenatal estradiol.

Reference : The alpha-fetoprotein knock-out mouse model suggests that parental behavior is sexually ...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Neurology Human health sciences : Endocrinology, metabolism & nutrition
	To cite this reference:	http://hdl.handle.net/2268/70007

Title :	The alpha-fetoprotein knock-out mouse model suggests that parental behavior is sexually differentiated under the influence of prenatal estradiol.
Language :	English
Author, co-author :	Keller, Matthieu [INRA > UMR85 Physiologie de la Reproduction et des Comportements >]
	Pawluski, Jodi [Maastricht University (The Netherlands) > Faculty of Health, Medicine and Life Science > Department of Psychiatry and Neuropsychology >]
	Brock, Olivier [Université de Liège - ULg > > > Doct. sc. (biol. orga. & écol. - Bologne)]
	Douhard, Quentin [Université de Liège - ULg > > Génétique >]
	Bakker, Julie [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]
Publication date :	2010
Journal title :	Hormones & Behavior
Publisher :	Academic Press
Audience :	International
ISSN :	0018-506X
e-ISSN :	1095-6867
City :	San Diego
Country :	CA
Keywords :	[en] hormones ; brain ; behavior
Abstract :	[en] In rodent species, sexual differentiation of the brain for many reproductive processes depends largely on estradiol. This was recently confirmed again by using the α-fetoprotein knockout (AFP-KO) mouse model, which lacks the protective actions of α-fetoprotein against maternal estradiol and as a result represents a good model to determine the contribution of prenatal estradiol to the sexual differentiation of the brain and behavior. In the present study, we determined whether parental responses are differentiated prenatally under the influence of estradiol. It was found that AFP-KO females showed longer latencies to retrieve pups to the nest and also exhibited lower levels of crouching over the pups in the nest in comparison to WT females. Thus our results suggest that prenatal estradiol defeminizes the parental brain in mice.
Research units :	Giga-Neurosciences
Funders :	NICHD
Target :	Researchers ; Students
Permalink :	http://hdl.handle.net/2268/70007

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