Reference : Female sexual maturation and reproduction after prepubertal exposure to estrogens and en...
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/69898
Female sexual maturation and reproduction after prepubertal exposure to estrogens and endocrine disrupting chemicals: A review of rodent and human data
English
Rasier, Gregory mailto [> > > >]
Toppari, Jorma [> > > >]
Parent, Anne-Simone mailto [Université de Liège - ULg > Département des sciences cliniques > Pédiatrie >]
Bourguignon, Jean-Pierre mailto [Université de Liège - ULg > Département des sciences cliniques > Pédiatrie >]
25-Jul-2006
Molecular & Cellular Endocrinology
Elsevier Ireland Ltd
254-255
187-201
Yes (verified by ORBi)
International
0303-7207
Clare
[en] female puberty ; endocrine disrupters
[en] Natural hormones and some synthetic chemicals spread into our surrounding environment share the capacity to interact with hormone action and metabolism. Exposure to such compounds can cause a variety of developmental and reproductive detrimental abnormalities in wildlife species and, potentially, in human. Many experimental and epidemiological data have reported that exposure of the developing fetus or neonate to environmentally relevant concentrations of some among these endocrine disrupters induces morphological, biochemical and/or physiological disorders in brain and reproductive organs, by interfering with the hormone actions. The impact of such exposures on the hypothalamic-pituitary-gonadal axis and subsequent sexual maturation is the subject of the present review. We will highlight epidemiological human studies and the effects of early exposure during gestational, perinatal or postnatal life in female rodents. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Commission européenne : Direction générale de la Recherche ; Belgian Study Group for Pediatric Endocrinology
http://hdl.handle.net/2268/69898
10.1016/j.mce.2006.04.002

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