Reference : Evaluation de la thymopoiese: applications cliniques.
Scientific journals : Article
Human health sciences : Hematology
http://hdl.handle.net/2268/6982
Evaluation de la thymopoiese: applications cliniques.
French
[en] Evaluation of thymopoiesis: clinical applications]
Castermans, Emilie mailto [Université de Liège - ULg > Département des sciences cliniques > Hématologie - Oncologie médicale >]
Morrhaye, Gabriel mailto [Université de Liège - ULg > > Centre d'immunologie >]
Marchand, S. [Université de Liège - ULg > > Centre d'immunologie >]
Martens, Henri mailto [Centre Hospitalier Universitaire de Liège - CHU > > Maladies infectieuses et médecine interne générale >]
Moutschen, Michel mailto [Université de Liège - ULg > > Centre d'immunologie - Embryologie >]
Geenen, Vincent mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Beguin, Yves mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Baron, Frédéric mailto [> > > >]
2007
Revue Médicale de Liège
62
12
725-9
Yes (verified by ORBi)
0370-629X
Belgium
[en] Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aging/immunology ; Cell Differentiation/immunology ; Child ; Gene Rearrangement, T-Lymphocyte/genetics ; Graft vs Host Disease/immunology ; Hematopoietic Stem Cell Transplantation ; Homeostasis/immunology ; Humans ; Immunologic Memory/immunology ; Lymphopoiesis/immunology ; Middle Aged ; Neurosecretory Systems/immunology ; Receptors, Antigen, T-Cell/genetics ; Recombination, Genetic/genetics ; T-Lymphocytes/immunology ; Thymus Gland/immunology ; Transplantation Immunology/immunology
[en] In the precedent article, we have described how T-cell generation in the thymus (thymopoiesis) may be currently evaluated through quantification by PCR of T-cell receptor excision circles (TREC) generated by intrathymic random recombination of the gene segments coding for variable parts of T-cell receptor for antigen (TCR). In hematology, TREC methodology helps in a better understanding of immune reconstitution after graft of hematopoietic stem cells: first there is a proliferation of mature T cells present in the graft, then a differentiation of naive T cells. In geriatrics, the homeostasis of the peripheral T-cell repertoire is maintained through proliferation of peripheral memory T cells rather than through thymic generation of naive T cells. In addition, TREC quantification constitutes a novel major tool for deciphering the tight control of thymopoiesis by the neuroendocrine system.
http://hdl.handle.net/2268/6982

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