Reference : Evaluation clinique de la fonction du thymus.
Scientific journals : Article
Human health sciences : Hematology
http://hdl.handle.net/2268/6981
Evaluation clinique de la fonction du thymus.
French
[en] Clinical evaluation of thymic function
Castermans, Emilie mailto [Université de Liège - ULg > Département des sciences cliniques > Hématologie - Oncologie médicale >]
Morrhaye, Gabriel mailto [Université de Liège - ULg > > Centre d'immunologie >]
Marchand, S. [> > > >]
Martens, Henri mailto [Université de Liège - ULg > > Centre d'immunologie >]
Moutschen, Michel mailto [Centre Hospitalier Universitaire de Liège - CHU > > Maladies infectieuses et médecine interne générale >]
Baron, Frédéric mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Beguin, Yves mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Geenen, Vincent mailto [Université de Liège - ULg > > Centre d'immunologie - Embryologie >]
2007
Revue Médicale de Liège
62
11
675-8
Yes (verified by ORBi)
0370-629X
Belgium
[en] DNA, Circular ; Gene Rearrangement, T-Lymphocyte/immunology ; Humans ; Polymerase Chain Reaction ; Positron-Emission Tomography ; Receptors, Antigen, T-Cell/metabolism ; T-Lymphocytes/immunology ; Thymus Gland/physiology/radionuclide imaging
[en] The essential role of the thymus is to install an extremely diverse repertoire of T lymphocytes that are self-tolerant and competent against non-self, as well as to generate self-antigen specific regulatory T cells (Treg) able to inactivate in periphery self-reactive T cells having escaped the thymic censorship. Although indirect, techniques of medical imaging and phenotyping of peripheral T cells may help in the investigation of thymic function. Nowadays however, thymopoiesis is better evaluated through quantification by PCR of T-cell receptor excision circles (TREC) generated by intrathymic random recombination of the gene segments coding for the variable parts of the T-cell receptor for antigen (TCR). The TREC methodology is very valuable in the circumstances not associated with intense proliferation or apoptosis of peripheral T lymphocytes.
http://hdl.handle.net/2268/6981

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