Reference : Pulmonary function, airway cytology and bronchoalveolar lavage fluid drug concentrati...
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/69729
Pulmonary function, airway cytology and bronchoalveolar lavage fluid drug concentration after aerosol administration of cefquinome to horses
English
Art, Tatiana mailto [Université de Liège - ULg > Département de sciences fonctionnelles > Phys. neuro-muscul., de l'effort - Méd. sport. des animaux >]
Ramery, Eve mailto [Université de Liège - ULg > Département de sciences fonctionnelles > Physiologie - Biochimie >]
Fraipont, Audrey mailto [Université de Liège - ULg > Département de sciences fonctionnelles > Physiologie >]
Lekeux, Pierre mailto [Université de Liège - ULg > Département de sciences fonctionnelles > Physiologie - Doyen de la Faculté de Médecine vétérinaire >]
2010
Equine Veterinary Education
Equine Veterinary Journal
22
9
473-479
Yes
International
0957-7734
Newmarket
United Kingdom
[en] horse ; aerosol ; antibiotherapy ; respiratory disease ; myeloperoxydase
[en] The administration of antibiotics by aerosol to horses suffering from respiratory infections may partially circumvent the limitations of antimicrobial therapy, e.g. large injection volumes, low bioavailability and risk of diarrhea. Only injectable formulations are available currently and usually contain other substances that could irritate the mucosa and induce coughing and bronchospasm. In addition, the quality of the aerosol, particularly in terms of the delivery of antibiotics to the deep parts of the lung, is unknown. Although used under field conditions, cefquinome delivered by aerosol has never been studied in horses. This study examined the safety of cefquinome injectable solution, administered by aerosol at a dose of 225 mg/inhalation to 7 healthy horses, by assessing (1) pulmonary function before and 15 min after a single inhalation, at the first day (Day 1) and the fifth day (Day 5) of a 5 day period treatment; and (2) the inflammatory status of the lung, i.e. percentage neutrophils and myeloperoxidase concentration, based on bronchoalveolar lavage (BAL) at D1 and D5. In addition, cefquinome concentrations were measured in bronchoalveolar lavage fluid after aerosol, intravenous (i.v.) and intramuscular (i.m.) administrations. A single aerosol of cefquinome injectable solution did not induce any immediate nor delayed pulmonary side effects in healthy horses and produced cefquinome concentrations in bronchoalveolar lavage (BAL) within 30 min that were higher than the minimal inhibitory concentration of the main equine respiratory pathogens. These results should stimulate further studies, especially in horses suffering from bronchial hyper-reactivity. Aerosol delivery of antibiotics may well have a role in equine therapeutics.
Researchers ; Professionals
http://hdl.handle.net/2268/69729
10.1111/j.2042-3292.2010.00116.x

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
ArtT_EquineVetEduc_2010.pdfPublisher postprint109.57 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.