Reference : Infections after allogeneic hematopoietic stem cell transplantation with a nonmyeloablat...
Scientific journals : Article
Human health sciences : Hematology
http://hdl.handle.net/2268/6972
Infections after allogeneic hematopoietic stem cell transplantation with a nonmyeloablative conditioning regimen.
English
Frere, Pascale mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Baron, Frédéric mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Bonnet, Christophe mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Hafraoui, Kaoutar mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Pereira-Martins, Maguy mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Willems, Evelyne mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Fillet, Georges mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Beguin, Yves mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
2006
Bone Marrow Transplantation
Nature Publishing Group
37
4
411-8
Yes (verified by ORBi)
International
0268-3369
London
United Kingdom
[en] Adrenal Cortex Hormones/adverse effects ; Belgium/epidemiology ; Carcinoma, Renal Cell/therapy ; Cytomegalovirus Infections/epidemiology/etiology ; Female ; Follow-Up Studies ; Graft vs Host Disease/prevention & control ; Hematologic Neoplasms/therapy ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Incidence ; Infection/epidemiology/etiology ; Male ; Middle Aged ; Multivariate Analysis ; Retrospective Studies ; Risk Factors ; Transplantation Conditioning/methods ; Transplantation, Homologous
[en] Hematopoietic cell transplantation (HCT) following nonmyeloablative conditioning (NMSCT) may be associated with a reduced risk of infection compared to standard allogeneic HCT. We retrospectively analyzed incidence and risk factors of infection in 62 patients undergoing NMSCT with low-dose TBI +/- fludarabine and postgrafting CsA and MMF. The proportion of patients with any infection was 77%, but the majority of infectious events occurred beyond day 30. Donor other than sibling, older age, early disease and male gender were significant risk factors. The incidence of bacteremia was 55% at 1 year and the number of bacteremic episodes was 0.9 per patient (0.08 before day 30). The risk of bacteremia increased with older age and the use of a donor other than an HLA-identical sibling, but not with neutropenia. The incidence of infections other than bacteremia correlated with the use of corticosteroids. The risk of CMV infection increased with high-risk CMV serology, and risk of CMV disease with high-risk CMV serology, older age, first transplantation and a diagnosis of lymphoma. In conclusion, after NMSCT, infections are not frequent in the first 30 days post transplant but careful long-term monitoring is necessary thereafter.
http://hdl.handle.net/2268/6972
10.1038/sj.bmt.1705255

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