Reference : Effective treatment of Jo-1-associated polymyositis with T-cell-depleted autologous p...
Scientific journals : Article
Human health sciences : Hematology
Human health sciences : Rheumatology
http://hdl.handle.net/2268/6962
Effective treatment of Jo-1-associated polymyositis with T-cell-depleted autologous peripheral blood stem cell transplantation.
English
Baron, Frédéric mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Ribbens, Clio mailto [Centre Hospitalier Universitaire de Liège - CHU > > Rhumatologie >]
Kaye, O. [> > > >]
Fillet, Georges mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Malaise, Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Rhumatologie >]
Beguin, Yves mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
2000
British Journal of Haematology
Blackwell Publishing
110
2
339-342
Yes (verified by ORBi)
International
0007-1048
1365-2141
Oxford
United Kingdom
[en] Adenovirus Infections, Human/etiology ; Adult ; Autoimmune Diseases/blood/immunology/therapy ; Cystitis/etiology ; Cytomegalovirus Infections/etiology ; Female ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Karnofsky Performance Status ; Liver Function Tests ; Lymphocyte Depletion/methods ; Polymyositis/blood/immunology/therapy ; Respiratory Distress Syndrome, Adult/etiology ; Respiratory Function Tests ; Treatment Outcome
[en] A patient with Jo-1 antibody-associated polymyositis (Jo-1 PM) had a Karnofsky score of 40% and severe muscle, liver and lung damage that was refractory to standard therapy. The female patient received an autologous T-cell-depleted haematopoietic stem cell transplant (HSCT) after myeloablative conditioning. The transplant procedure was complicated by severe adult respiratory distress syndrome (ARDS) and adenovirus-associated haemorrhagic cystitis as well as cytomegalovirus (CMV) reactivation. The patient's creatinine phosphokinase (CPK) and alanine transaminase (ALT) values were normal on day 21. The patient's strength has improved remarkably and her dyspnoea is subjectively improved. At 15 months after the transplant, the patient was well with a Karnofsky score of 80% and had been off any therapy, including steroids, for 14 months.
Researchers ; Professionals
http://hdl.handle.net/2268/6962

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