Reference : Le cas clinique du mois. Sclérose hepato-portale chez un patient traité par azathioprine
Scientific journals : Article
Human health sciences : Gastroenterology & hepatology
Le cas clinique du mois. Sclérose hepato-portale chez un patient traité par azathioprine
[en] Clinical case of the month. Hepatoportal sclerosis in a patient treated with azathioprine
Roland, S. [> > > >]
Delwaide, Jean mailto [Centre Hospitalier Universitaire de Liège - CHU > > Gastro-Entérologie-Hépatologie >]
Cornet, G. [ > > ]
Mahieu, Ph [ > > ]
Jacquet, N. [ > > ]
Belaiche, Jacques mailto [Université de Liège - ULg > > Gastro-Entérologie-Hépatologie >]
Revue Médicale de Liège
Hopital de Baviere
Yes (verified by ORBi)
[en] Adult ; Ascites/chemically induced ; Azathioprine/adverse effects ; Cholestasis/chemically induced ; Diagnosis, Differential ; Hepatitis, Toxic/diagnosis/etiology ; Humans ; Hypertension, Portal/chemically induced/diagnosis ; Immunosuppressive Agents/adverse effects ; Kidney Transplantation ; Liver Cirrhosis/chemically induced/diagnosis ; Male
[en] We report a case of hepatoportal sclerosis in a renal transplant patient treated with azathioprine. The initial symptom was ascites. On the biochemical level, there were cholestasis without cytolysis or hepatocellular insufficiency. A presinusoidal portal hypertension was found on haemodynamic studies, without portal thrombosis at CT-scan. A diagnosis of hepatoportal sclerosis was evoked on histology and attributed to azathioprine. This case gives an illustration of a classical albeit rare complication of azathioprine. The indolent pattern of the disease and the risk of variceal bleeding point out the need for a hepatic follow-up during the treatment.
Researchers ; Professionals

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