[en] We report a case of hepatoportal sclerosis in a renal transplant patient treated with azathioprine. The initial symptom was ascites. On the biochemical level, there were cholestasis without cytolysis or hepatocellular insufficiency. A presinusoidal portal hypertension was found on haemodynamic studies, without portal thrombosis at CT-scan. A diagnosis of hepatoportal sclerosis was evoked on histology and attributed to azathioprine. This case gives an illustration of a classical albeit rare complication of azathioprine. The indolent pattern of the disease and the risk of variceal bleeding point out the need for a hepatic follow-up during the treatment.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Roland, S.
Delwaide, Jean ; Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
Cornet, G.
Mahieu, Ph
Jacquet, N.
Belaiche, Jacques ; Université de Liège - ULiège > Gastro-Entérologie-Hépatologie
Language :
French
Title :
Le cas clinique du mois. Sclérose hepato-portale chez un patient traité par azathioprine
Alternative titles :
[en] Clinical case of the month. Hepatoportal sclerosis in a patient treated with azathioprine