Reference : Plasma Na-K ATPase inhibitor activity and intracellular ions during hemodialysis
Scientific journals : Article
Human health sciences : Urology & nephrology
Plasma Na-K ATPase inhibitor activity and intracellular ions during hemodialysis
Krzesinski, Jean-Marie mailto [Université de Liège - ULg > > Néphrologie >]
Du, F. [> > > >]
Pequeux, M. L. [> > > >]
Rorive, Georges mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
International Journal of Artificial Organs
Wichtig Editore
Yes (verified by ORBi)
[en] Hemodialysis ; Sodium ; Calcium ; Erythrocytes ; Platelets ; Endogenous digitalis-like activity
[en] We have investigated the relationship between plasma Na-K ATPase inhibitor activity (EDLS) and intracellular ions in 37 uremic hemodialysed hypertensive patients, and in 20 normotensive non uremic controls (NC). As compared with the NC population, significantly enhanced values for erythrocyte (RBC) Na, Ca, platelet cytosolic Ca and EDLS were observed in all the uremic patients tested just before a dialysis session, as well as a decrease in RBC Ca ATPase and in the platelet pH. In uremia, significant correlations have been noted between RBC Na and platelet Ca (r = 0.6) or systolic BP (r = 0.45); between platelet Ca and systolic blood pressure (r = 0.8) or diastolic BP (r = 0.5) and between EDLS and RBC Na, Ca or platelet Ca (r = 0.5). Anti-hypertensive treatment has no influence on these parameters. During dialysis, a significant decrease has been noted in RBC Na, Ca, platelet Ca, SBP (only in untreated patients) and EDLS and an increase in RBC Ca ATPase and platelet pH. These modifications are significantly correlated with the weight change.
Researchers ; Professionals

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