ORBi: MELIN Pierrette - How many women can benefit from a full intrapartum antibiotic prphylaxis for prevention of perinatal group B streptococcal disease?

Reference : How many women can benefit from a full intrapartum antibiotic prphylaxis for prevention ...


	Document type :	Scientific congresses and symposiums : Paper published in a book
	Discipline(s) :	Human health sciences : Immunology & infectious disease Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)
	To cite this reference:	http://hdl.handle.net/2268/68515

Title :	How many women can benefit from a full intrapartum antibiotic prphylaxis for prevention of perinatal group B streptococcal disease?
Language :	English
Author, co-author :	MELIN, Pierrette [Centre Hospitalier Universitaire de Liège - CHU > > Microbiologie médicale >]
	Lorquet, Sophie [ > > ]
	Rodriguez Cuns, Grisel [Universitad de la Republica, Montevideo, Uruguay > > > >]
	Foidart, J. M. [Université de Liège - ULg > Gynécologie Obstétrique > > >]
	De Mol, Patrick [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale >]
Publication date :	Nov-2004
Main document title :	Program and Abstracts of the 44th Intersciences Conference on Antimicrobial Agents and Chemotherapy
Editor :	American Society of Microbiology
Publisher :	American Society for Microbiology (ASM)
Pages :	Abstract du poster G-499
On invitation :	No
Audience :	International
City :	Washington
Country :	USA
Event name :	44th Intersciences Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
Event date :	du 30 octobre au 2 novembre 2004
Event organizer :	American Society of Microbiology
Event place (city) :	Washington
Event country :	USA
Keywords :	[en] Group B streptococci ; perinatal infections ; intrapartum antibiotic prophylaxis ; pregnant women
Abstract :	[en] Background: In Belgium as in many Western countries, GBS are still the leading cause of severe perinatal infections. Current guidelines for prevention recommend intrapartum antimicrobial prohylaxis (IAP) administered promptly before delivery to pregnant women colonized with GBS. The risk of vertical GBS transmission to the newborn decreases as the duration of prophylaxis increases. The considered threshold for prophylaxis adequacy is the first dose administered at least 4 hours before delivery. Objective: To evaluate the proportion of pregnant women who could benefit from an adequate IAP for the prevention of GBS perinatal infections. Methods: Between June and October 2003, we recorded in two hospitals the elapse time between admission for labor and delivery. We assumed 5 hours represent a useful threshold to allow admission, revision of chart and administration of adequate IAP. The status of vaginal colonization with GBS was determined by CDC’s recommended culture method with Granada agar added. Results: Among 532 women, 27.3 % delivered within 5 hours after admission for labor. The colonization rate for GBS was 25.6 %. The distribution of elapse time between admission and delivery for GBS colonized pregnant women was not significantly different from non colonized women (p <= 1). Conclusions: 1) With the current prevention strategy, 27.3 % of these pregnant women would not have benefit from adequate prophylaxis 2) These results highlight the importance of an efficient organization to warranty prompt administration of IAP as soon as possible when mandatory. 3) If a rapid intrapartum screening test is used, no delay can be afforded “from ward to bench to bed”.
Research units :	Centre National de Référence des Streptocoques du Groupe B
Target :	Professionals
Permalink :	http://hdl.handle.net/2268/68515

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Open access	Time to delivery ICAAC 2004.pdf		Publisher postprint	487.49 kB	View/Open

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