Reference : Abnormal neural filtering of irrelevant visual information in depression.
Scientific journals : Article
Human health sciences : Psychiatry
http://hdl.handle.net/2268/68307
Abnormal neural filtering of irrelevant visual information in depression.
English
Desseilles, Martin mailto [Université de Liège - ULg > Département des sciences cliniques > Psychiatrie et psychologie médicale >]
Balteau, Evelyne mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Sterpenich, Virginie [> > > >]
Dang Vu, Thien Thanh [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Darsaud, Annabelle [> > > >]
Vandewalle, Gilles mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Albouy, Genevieve [> > > >]
Salmon, Eric mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Peters, Frederic [> > > >]
Schmidt, Christina [Université de Liège - ULg > Centre de Recherches du Cyclotron - Département des sciences cognitives > Neuropsychologie > > >]
Schabus, Manuel [> > > >]
Gais, Stephen [> > > >]
Degueldre, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Phillips, Christophe mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Luxen, André mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron >]
Ansseau, Marc mailto [Université de Liège - ULg > Département des sciences cliniques > Psychiatrie et psychologie médicale >]
Maquet, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Schwartz, Sophie [> > > >]
2009
Journal of Neuroscience
Society for Neuroscience
29
5
1395-403
Yes (verified by ORBi)
International
0270-6474
1529-2401
Washington
DC
[en] Adult ; Attention/physiology ; Brain Mapping/methods ; Depressive Disorder, Major/physiopathology/psychology ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Photic Stimulation/methods ; Psychomotor Performance/physiology ; Visual Cortex/physiology ; Visual Perception/physiology ; Young Adult
[en] The pathophysiology of major depressive disorder (MDD) includes both affective and cognitive dysfunctions. We aimed to clarify how regions regulating affective processing interact with those involved in attention, and how such interaction impacts perceptual processing within sensory cortices. Based on previous work showing that top-down influences from attention can determine the processing of external inputs within early sensory cortices, we tested with functional magnetic resonance imaging (fMRI) whether MDD alters attentional ("top-down") effects on the neural filtering of irrelevant, nonemotional visual stimuli. The present fMRI study was conducted in 14 nonmedicated patients with a first episode of unipolar MDD and 14 matched controls. During scanning, subjects performed two tasks imposing two different levels of attentional load at fixation (easy or difficult), while irrelevant colored stimuli were presented in the periphery. Analyses of fMRI data revealed that MDD patients show (1) an abnormal filtering of irrelevant information in visual cortex, (2) an altered functional connectivity between frontoparietal networks and visual cortices, and (3) a hyperactivity in subgenual cingulate/medial orbitofrontal cortex that was modulated by attentional load. These results demonstrate that biological abnormalities contribute to the cognitive deficits seen in major depression, and clarify how neural networks implicated in mood regulation influence executive control and perceptual processes. These findings not only improve our understanding of the pathophysiological mechanisms underlying cognitive dysfunctions in MDD, but also shed new light on the interaction between cognition and mood regulation.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals
http://hdl.handle.net/2268/68307
also: http://hdl.handle.net/2268/40294 ; http://hdl.handle.net/2268/60396
10.1523/JNEUROSCI.3341-08.2009

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