Reference : New Strategy for the Preparation of Clickable Peptides and Labeling with 1-(Azidomethyl)...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/67849
New Strategy for the Preparation of Clickable Peptides and Labeling with 1-(Azidomethyl)-4-[18F]-fluorobenzene for PET
English
Thonon, David mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Paris, Jérôme mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Kech, Cecile [ > > ]
Lemaire, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Luxen, André mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron >]
26-Mar-2009
Bioconjugate Chemistry
American Chemical Society
20
4
817-823
Yes (verified by ORBi)
International
1043-1802
1520-4812
Washington
DC
[en] The alkyne-azide Cu(I)-catalyzed Huisgen cycloaddition, a click type reaction was used to label a peptide with
fluorine-18. A novel solid phase synthesis approach for the preparation of clickable peptides has been developed
and has also permitted the straightforward preparation of reference compounds. A complementary azide labeling
agent (1-(azidomethyl)-4-[18F]-fluorobenzene) has been produced in a four step procedure in 75 min with a 34%
radiochemical yield (decay corrected). Conjugation of [18F]fluoroazide with a model alkyne-neuropeptide produced
the desired 18F-radiolabeled peptide in less than 15 min with a yield of 90% and excellent radiochemical purity
http://hdl.handle.net/2268/67849
10.1021/bc800544p

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