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| Reference : New Strategy for the Preparation of Clickable Peptides and Labeling with 1-(Azidomethyl)... |
| Scientific journals : Article | |||
| Physical, chemical, mathematical & earth Sciences : Chemistry | |||
| http://hdl.handle.net/2268/67849 | |||
| New Strategy for the Preparation of Clickable Peptides and Labeling with 1-(Azidomethyl)-4-[18F]-fluorobenzene for PET | |
| English | |
Thonon, David  [Université de Liège - ULg > > Centre de recherches du cyclotron >] | |
| Paris, Jérôme [Université de Liège - ULg > > Centre de recherches du cyclotron >] | |
| Kech, Cecile [ > > ] | |
| Lemaire, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >] | |
| Luxen, André [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron >] | |
| 26-Mar-2009 | |
| Bioconjugate Chemistry | |
| American Chemical Society | |
| 20 | |
| 4 | |
| 817-823 | |
| International | |
| 1043-1802 | |
| 1520-4812 | |
| Washington | |
| DC | |
| [en] The alkyne-azide Cu(I)-catalyzed Huisgen cycloaddition, a click type reaction was used to label a peptide with
fluorine-18. A novel solid phase synthesis approach for the preparation of clickable peptides has been developed and has also permitted the straightforward preparation of reference compounds. A complementary azide labeling agent (1-(azidomethyl)-4-[18F]-fluorobenzene) has been produced in a four step procedure in 75 min with a 34% radiochemical yield (decay corrected). Conjugation of [18F]fluoroazide with a model alkyne-neuropeptide produced the desired 18F-radiolabeled peptide in less than 15 min with a yield of 90% and excellent radiochemical purity | |
| http://hdl.handle.net/2268/67849 | |
| 10.1021/bc800544p |
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