Reference : P65 Homodimer Activity in Distal Airway Cells Determines Lung Dysfunction in Equine Heaves
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/6740
P65 Homodimer Activity in Distal Airway Cells Determines Lung Dysfunction in Equine Heaves
English
Sandersen, Charlotte mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés >]
Bureau, Fabrice mailto [Université de Liège - ULg > Département de sciences fonctionnelles > Biochimie et biologie moléculaire >]
Turlej, R. [> > > >]
Fievez, Laurence mailto [Université de Liège - ULg > Département de sciences fonctionnelles > Biochimie et biologie moléculaire >]
Dogne, S. [> > > >]
Kirschvink, N. [> > > >]
Lekeux, Pierre mailto [Université de Liège - ULg > Département de sciences fonctionnelles > Physiologie >]
10-Aug-2001
Veterinary Immunology and Immunopathology
Elsevier Science
80
3-4
315-26
Yes (verified by ORBi)
International
0165-2427
Amsterdam
The Netherlands
[en] Nuclear factor-κB ; Lung resistance ; Inflammation ; Neutrophils
[en] Nuclear factor-kappaB (NF-kappaB) activity, which is a key regulator of inflammatory gene expression, is increased in bronchial epithelial cells from horses suffering from heaves (a hypersensitivity-associated inflammatory condition of the lung). To determine whether this increased activity extends to distal airways and to other pulmonary cells, cells recovered by broncho-alveolar lavage (BAL) in healthy and heaves-affected horses were assessed for NF-kappaB activity. NF-kappaB activity was much higher in BAL cells from heaves-affected horses, especially during crisis (disease exacerbation), than in cells from healthy horses. Moreover, the level of NF-kappaB activity found in BAL cells was positively correlated to total lung resistance and to the proportion of neutrophils present in BAL fluid. Finally, prototypical p65-p50 NF-kappaB heterodimers were absent from BAL cells, which mostly contained p65 homodimers. These results (1) show that increased NF-kappaB activity is a general feature of heaves lung; (2) demonstrate the importance of p65 homodimers in neutrophilic inflammation; and (3) suggest that the use of specific NF-kappaB inhibitors could improve lung function in heaves-affected horses.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/6740
10.1016/S0165-2427(01)00329-4

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