[en] Oxidative stress has become of increasing interest in research and in equine and human medicine. If the pro-oxidant burden overwhelms the endogenous antioxidant defence of the organism, the arising imbalance between pro- and antioxidants is defined as oxidative stress. Different pathways might increase the generation of reactive oxygen species ( ROS) and results in oxidative stress. In physiological conditions, like during moderated exercise, the balance between ROS production and antioxidants allows to maintain an optimal organic function. In the light of the potentially deleterious role of excessive ROS production and the evidence that exercise-induced oxidative stress occurs in horses, the assessment of the antioxidant status should be considered in sport horses. Recent researches indicate that oxidative stress may play a role in physiopathology of several pathological syndromes in horses. Therefore, with classical treatment, the controlled administration of antioxidants appears interesting for the modulation of these processes, as well as in sport horses during intense exercise period. [fr] Le stress oxydant est de plus en plus étudié tant dans le domaine de la recherche qu’en médecine humaine et équine. Il a été défini comme un déséquilibre prononcé entre les éléments antioxydants et oxydants en faveur de ces derniers et de leurs effets potentiellement néfastes. Les origines du stress oxydant sont multiples et résultent d’une formation de formes réactives de l’oxygène (FRO) au sein de l’organisme. En condition physiologique, comme par exemple au cours d’un exercice réalisé de façon modérée, l’équilibre entre la production des FRO et les systèmes de défenses antioxydantes permet le maintien d’une fonction organique optimale. Mais à la lumière du rôle potentiellement délétère que peut induire une production excessive de FRO et du fait que le stress oxydant induit par l’exercice existe chez le cheval, la prise en compte du stress oxydant chez le cheval de sport n’est plus à négliger. De plus, des recherches récentes suggèrent que le stress oxydant intervient dans la physiopathologie ou dans la genèse de certaines entités pathologiques chez le cheval et pourrait être partiellement associé à un déficit d’apports d’éléments antioxydants. Dès lors, en appui au traitement classique, l’administration contrôlée d’antioxydants semble être justifiée au cours de ces phénomènes, ou chez le cheval de sport au cours d’une période d’exercice intense.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
De Moffarts, Brieuc; Université de Liège - ULiège
Kirschvink, Nathalie
Pincemail, Joël ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie cardio-vasculaire
Lekeux, Pierre ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie
Language :
French
Title :
Impact physiologique et pathologique du stress oxydant chez le cheval
Alternative titles :
[en] Physiological and pathological impact of oxidative stress in the equine species
Publication date :
2005
Journal title :
Annales de Médecine Vétérinaire
ISSN :
0003-4118
eISSN :
1781-3875
Publisher :
Annales Medecine Veterinaire, Liege, Belgium
Volume :
149
Issue :
1
Pages :
1-9
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
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