Reference : Outcome from status epilepticus after portosystemic shunt attenuation in 3 dogs treat...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/67166
Outcome from status epilepticus after portosystemic shunt attenuation in 3 dogs treated with propofol and phenobarbital
English
Gommeren, Kris mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Unité des Soins Intensifs > >]
Claeys, Stéphanie mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Chirurgie des Animaux de Compagnie > >]
de Rooster, Hilde [Universiteit Gent - Ugent > > > > >]
Hamaide, Annick mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Chirurgie des Animaux de Compagnie > >]
Daminet, Sylvie [Universiteit Gent - Ugent > > > > >]
Jun-2010
Journal of Veterinary Emergency and Critical Care
Blackwell
20
3
346-351
Yes (verified by ORBi)
International
1479-3261
1476-4431
Oxford
United Kingdom
[en] ameroid constrictor ; canine ; postoperative complication ; seizure
[en] OBJECTIVE: To describe outcome of treatment with propofol and phenobarbital for status epilepticus (SE) after portosystemic shunt (PSS) attenuation. CASE OR SERIES SUMMARY: Three dogs without preceding seizure activity, were diagnosed with a single extrahepatic PSS. Following standard preoperative medical therapy, an ameroid constrictor was placed surgically. Recovery was uneventful until spontaneous SE developed 46-96 hours after surgery. After unsuccessful seizure control with benzodiazepines, dogs were treated with a bolus of propofol followed by a propofol constant rate infusion. Phenobarbital was concurrently administered and supportive care was optimized. All dogs recovered uneventfully over the next 7-9 days. Over the following months phenobarbital was slowly tapered. All dogs have been free from antiepileptic drugs for several months, without recurrence of neurologic signs. NEW OR UNIQUE INFORMATION PROVIDED: In this case series, we describe the treatment of 3 dogs with propofol and phenobarbital for refractory SE following attenuation of a single congenital PSS. After weaning of the propofol constant rate infusion, and tapering and discontinuation of phenobarbital over the following months, all dogs experienced a complete recovery. This study provides evidence that use of propofol in combination with phenobarbital may be efficacious for management of SE in dogs after PSS surgery.
Professionals ; Students
http://hdl.handle.net/2268/67166
10.1111/j.1476-4431.2010.00537.x

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