Reference : The Effect of Intravenous Administration of Web 2086 on Paf-Induced Platelet Aggregation...
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/6710
The Effect of Intravenous Administration of Web 2086 on Paf-Induced Platelet Aggregation in Healthy Friesian Calves
English
Bastos da Silva, Miriam [Université de Liège - ULG > Faculty of Veterinary Medicine > Laboratory of Functional Investigation > >]
Gustin, Pascal mailto [Université de Liège - ULg > Faculty of Veterinary Medicine > Laboratory of Pharmacology and Toxicology > >]
Herion, Francine mailto [Centre Hospitalier Universitaire de Liège - CHU > Thrombosis Homestasis Unit > > >]
Raskinet, Renée [Centre Hospitalier Universitaire de Liège - CHU > Thrombosis Homestasis Unit > > >]
David, Jean-Louis [Centre Hospitalier Universitaire de Liège - CHU > Thrombosis Homestasis Unit > > >]
Gougnard, Thierry [Centre Hospitalier Universitaire de Liège - CHU > Laboratory of Clinical Toxicology > > >]
Plomteux, Guy mailto [Centre Hospitalier Universitaire de Liège - CHU > Laboratory of clinical toxicology > > >]
Desmecht, Daniel mailto [Université de Liège - ULg > Faculty of Veterinary Medicine > Laboratory of Functional Investigation > >]
Lekeux, Pierre mailto [Université de Liège - ULg > Faculty of Veterinary Medicine > Laboratory of Functional Investigation > >]
1997
Veterinary Research Communications
Kluwer Academic Publishers
21
7
521-531
Yes (verified by ORBi)
International
0165-7380
Dordrecht
The Netherlands
[en] aggregation ; cattle ; chromatography ; platelet ; platelet-activating factor ; platelet-rich plasma ; thienotriazolodiazepine
[en] The in vivo ability of the specific PAF-antagonist WEB 2086, a thienotriazolodiazepine, to inhibit platelet-activating factor (PAF) in cattle was investigated by in vitro determination of platelet aggregation curves. WEB 2086 was infused intravenously into a group of 5 healthy male Friesian calves in a dose of 3 mg/kg over 1 min. The resultant inhibition peaked between 30 min and 1 h after administration of WEB 2086. The inhibition was significantly reduced after 3 h and became non-significant after 6 h, but maximal pre-treatment aggregation had not been restored by 24 h after the injection of WEB 2086. These results confirm previous results obtained in vitro and suggest that WEB 2086 is a potent antagonist of PAF activity in calves. They also suggest that further clinical studies with WEB 2086 in cattle are desirable.
Bastos is a recipent of a grant from CNPq and FCAP Belém-Parà Brazil
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/6710

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