Reference : Oxytocin Facilitates Female Sexual Maturation through a Glia-to-Neuron Signaling Pathway
Scientific journals : Article
Human health sciences : Pediatrics
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
http://hdl.handle.net/2268/66962
Oxytocin Facilitates Female Sexual Maturation through a Glia-to-Neuron Signaling Pathway
English
Parent, Anne-Simone mailto [Université de Liège - ULg > Département des sciences cliniques > Pédiatrie >]
Rasier, Grégory [Université de Liège - ULg > > > Doct. sc. bioméd. & pharma. (Bologne)]
Matagne, V. [> > > >]
Lomniczi, A. [> > > >]
LEBRETHON, Marie-Christine mailto [Centre Hospitalier Universitaire de Liège - CHU > > Pédiatrie >]
Gerard, Arlette mailto [Centre Hospitalier Universitaire de Liège - CHU > > Pédiatrie >]
Ojeda, S. R. [> > > >]
Bourguignon, Jean-Pierre mailto [Université de Liège - ULg > Département des sciences cliniques > Pédiatrie >]
Mar-2008
Endocrinology
149
3
1358-65
Yes (verified by ORBi)
International
0013-7227
[en] It has been earlier proposed that oxytocin could play a facilitatory role in the preovulatory LH surge in both rats and humans. We here provide evidence that oxytocin also facilitates sexual maturation in female rats. The administration of an oxytocin antagonist for 6 d to immature female rats decreased GnRH pulse frequency ex vivo and delayed the age at vaginal opening and first estrus. The in vitro reduction in GnRH pulse frequency required chronic blockade of oxytocin receptors, because it was not acutely observed after a single injection of the antagonist. Hypothalamic explants exposed to the antagonist in vitro showed a reduced GnRH pulse frequency and failed to respond to oxytocin with GnRH release. Prostaglandin E(2) (PGE(2)) mimicked the stimulatory effect of oxytocin on GnRH pulse frequency, and inhibition of PG synthesis blocked the effect of oxytocin, suggesting that oxytocin accelerates pulsatile GnRH release via PGE(2). The source of PGE(2) appears to be astrocytes, because oxytocin stimulates PGE(2) release from cultured hypothalamic astrocytes. Moreover, astrocytes express oxytocin receptors, whereas GnRH neurons do not. These results suggest that oxytocin facilitates female sexual development and that this effect is mediated by a mechanism involving glial production of PGE(2).
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
http://hdl.handle.net/2268/66962
10.1210/en.2007-1054

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