Reference : On the origin of bacterial resistance to penicillin: comparison of a beta-lactamase a...
Scientific journals : Article
Life sciences : Microbiology
http://hdl.handle.net/2268/66947
On the origin of bacterial resistance to penicillin: comparison of a beta-lactamase and a penicillin target
English
Kelly, Judith A. [University of Connecticut - UCONN > Departement of Molecular and Cell biology and Institute of Materials Science > > > >]
Dideberg, Otto [Université de Liège - ULg > Institut de Physique > Service de Cristallographie > > >]
Charlier, Paulette mailto [Université de Liège - ULg > Institut de Physique > Service de Cristallographie > >]
Wery, Jean-Pierre [Université de Liège - ULg > Institut de Physique > Service de Cristallographie > >]
Libert, M. [Université de Liège - ULg > Institut de Physique > Service de Cristallographie > >]
Moews, Paul [University of Connecticut - UCONN > Departement of Molecular and Cell biology and Institute of Materials Science > > > >]
Knox, James [University of Connecticut - UCONN > Departement of Molecular and Cell biology and Institute of Materials Science > > > >]
Duez, Colette mailto [Université de Liège - ULg > Institu de Chimie > Service de Microbiologie > >]
Fraipont, Claudine mailto [Université de Liège - ULg > Institu de Chimie > Service de Microbiologie > >]
Joris, Bernard mailto [Université de Liège - ULg > Institut de Chimie > Service de Microbiologie > >]
Dusart, Jean [Université de Liège - ULg > Institut de Chimie > Service de Microbiologie > > >]
Frère, Jean-Marie mailto [Université de Liège - ULg > Institut de Chimie > Service de Microbiologie > >]
Ghuysen, Jean-Marie [Université de Liège - ULg > Institut de Chimie > Service de Microbiologie > > >]
21-Mar-1986
Science
American Association for the Advancement of Science
231
1429-1431
Yes (verified by ORBi)
International
0036-8075
1095-9203
Washington
DC
[en] penicillin ; beta-lactamase ; resistance
[en] Structural data are now available for comparing a penicillin target enzyme, the D-alanyl-D-alanine-peptidase from Streptomyces R61, with a penicillin-hydrolyzing enzyme, the beta-lactamase from Bacillus licheniformis 749/C. Although the two enzymes have distinct catalytic properties and lack relatedness in their overall amino acid sequences except near the active-site serine, the significant similarity found by x-ray crystallography in the spatial arrangement of the elements of secondary structure provides strong support for earlier hypotheses that beta-lactamases arose from penicillin-sensitive D-alanyl-D-alanine-peptidases involved in bacterial wall peptidoglycan metabolism.
Researchers ; Professionals
http://hdl.handle.net/2268/66947

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