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Bacterial wall peptidoglycan, DD-peptidases and beta-lactam antibiotics
Ghuysen, Jean-Marie; Frère, Jean-Marie; Leyh-Bouille, Mélina et al.
1984In Scandinavian Journal of Infectious Diseases, 42, p. 17-37
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Keywords :
Amino Acyl-tRNA Synthetases/metabolism; Anti-Bacterial Agents/pharmacology; Bacteria/drug effects/metabolism; Cell Wall/metabolism; Chymotrypsin/metabolism; Dipeptidases/antagonists & inhibitors/metabolism; Models, Biological; Peptidoglycan/metabolism; Peptidyl Transferases/metabolism; Structure-Activity Relationship; beta-Lactams
Abstract :
[en] Wall peptidoglycan expansion in bacteria rests upon a cytoplasmic D-Ala: D-Ala ligase (ADP) which catalyses synthesis of a D-Ala-D-Ala dipeptide (with accompanying hydrolysis of one molecule of ATP) and a set of DD-peptidases which utilize this D-Ala-D-Ala dipeptide--once it has been translocated at the outer face of the plasma membrane as the C-terminal portion of a disaccharide peptide unit--as carbonyl donor for transpeptidation and carboxypeptidation reactions (without additional energy expenditure). Four DD-peptidases have been selected which differ from each other with respect to the effects that amino compounds exert on the fate and rate of consumption of a D-Ala-D-Ala terminated amide carbonyl donor analogue. They serve as models to understand the different mechanisms by which the DD-peptidases perform catalysis and show widely varying responses to the action of beta-lactams, from extreme sensitivity to very high resistance.
Disciplines :
Microbiology
Author, co-author :
Ghuysen, Jean-Marie ;  Université de Liège - ULiège
Frère, Jean-Marie ;  Université de Liège - ULiège
Leyh-Bouille, Mélina;  Université de Liège - ULiège
Nguyen-Distèche, Martine ;  Université de Liège - ULiège
Coyette, Jacques ;  Université de Liège - ULiège
Dusart, Jean;  Université de Liège - ULiège
Joris, Bernard ;  Université de Liège - ULiège
Duez, Colette ;  Université de Liège - ULiège
Dideberg, Otto;  Université de Liège - ULiège
Charlier, Paulette ;  Université de Liège - ULiège
Dive, Georges ;  Université de Liège - ULiège
Lamotte-Brasseur, Josette ;  Université de Liège - ULiège
Language :
English
Title :
Bacterial wall peptidoglycan, DD-peptidases and beta-lactam antibiotics
Publication date :
1984
Journal title :
Scandinavian Journal of Infectious Diseases
ISSN :
0036-5548
eISSN :
1651-1980
Publisher :
Taylor & Francis, Stockholm, Sweden
Volume :
42
Pages :
17-37
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 July 2011

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