Article (Scientific journals)
Guillain-Barré syndrome following hepatitis E
Loly, Jean-Philippe; Rikir, Estelle; Seivert, Maxime et al.
2009In World Journal of Gastroenterology, 15 (13), p. 1645-1647
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Keywords :
Gangliosides; Guillain-Barré syndrome; Hepatitis E; Molecular mimicry; Viral hepatitis
Abstract :
[en] Guillain-Barré syndrome (GBS) is often triggered by a preceding bacterial or viral infection. Occasionally, it has been observed in association with acute hepatitis A, B and C, and three cases have been previously described in India in which GBS was associated with acute hepatitis E. A molecular mimicry mechanism is supposed to be involved in the pathogenesis of GBS triggered by infectious agents, although the nature of the shared epitopes has not been characterized in most instances, including that in the case of hepatotropic viruses. We report a case of GBS following acute hepatitis E in a European individual. The presence of antiganglioside GM2 antibodies in this patient suggested molecular mimicry involving ganglioside GM2 in the pathogenesis of GBS associated with hepatitis E.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Loly, Jean-Philippe  ;  Université de Liège - ULiège > Frais communs médecine
Rikir, Estelle ;  Université de Liège - ULiège > Neurologie Sart Tilman
Seivert, Maxime ;  Université de Liège - ULiège > Frais communs médecine
Legros, E.;  Verviers > General Practitioner
Defrance, P.;  CHPLT La Tourelle > Hepato-Gastroenterology
Belaiche, Jacques ;  Université de Liège - ULiège > Gastro-Entérologie-Hépatologie
Moonen, Gustave  ;  Université de Liège - ULiège > Neurologie Sart Tilman
Delwaide, Jean ;  Université de Liège - ULiège > Gastro-Entérologie-Hépatologie
Language :
English
Title :
Guillain-Barré syndrome following hepatitis E
Publication date :
2009
Journal title :
World Journal of Gastroenterology
ISSN :
1007-9327
eISSN :
2219-2840
Publisher :
W J G Press, Beijing, China
Volume :
15
Issue :
13
Pages :
1645-1647
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 July 2010

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