Reference : Mode of interaction between β-lactam antibiotics and the exocellular DD-carboxypeptidase...
Scientific journals : Article
Life sciences : Microbiology
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/66812
Mode of interaction between β-lactam antibiotics and the exocellular DD-carboxypeptidase--transpeptidase from Streptomyces R39
English
Fuad, Noha [Université de Liège - ULg > Institut de Botanique > Service de Microbiologie > >]
Frère, Jean-Marie mailto [Université de Liège - ULg > Institut de Botanique > Service de Microbiologie > > > >]
Ghuysen, Jean-Marie [ULg > Institut de Botanique > Service de Microbiologie > >]
Duez, Colette mailto [Université de Liège - ULg > Institut de Botanique > Service de Microbiologie > >]
Iwatsubo, Motohiro [Centre National de la Recherche Scientifique - CNRS > Centre de Génétique Moléculaire > > >]
1976
Biochemical Journal
Portland Press
155
3
623-629
Yes (verified by ORBi)
International
0264-6021
1470-8728
London
United Kingdom
[en] carboxypeptidases/*antagonists & inhibitors ; cephalexin/pharmacology ; cephalosporins/*pharmacology ; fluorescence ; kinetics ; muramoylpentapeptide carboxypeptidase/*antagonists & inhibitors ; penicillins/*pharmacology ; spectrum analysis ; streptomyces/*enzymology
[en] The exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R39 is inhibited by beta-lactam antibiotics according to the same general scheme of reaction as the exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R61. However, the values for the kinetic constants involved in the reaction are very different for the two enzymes and provide an explanation for the observation that the R39 enzyme is more sensitive to beta-lactam antibiotics than the R61 enzyme. Further, particular beta-lactams influence the kinetic constants to different extents depending on the source of the enzyme, so that a physical basis for the spectrum of antibiotic activity against particular enzyme systems is provided.
Fonds de la Recherche Fondamentale Collective - FRFC
Researchers ; Professionals
http://hdl.handle.net/2268/66812
also: http://hdl.handle.net/2268/91728

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