Reference : H3-receptor regulation of vascular gastrin and somatostatin releases by the isolated rat...
Scientific journals : Article
Human health sciences : Gastroenterology & hepatology
http://hdl.handle.net/2268/66600
H3-receptor regulation of vascular gastrin and somatostatin releases by the isolated rat stomach.
English
Bado, A. [> > > >]
Moizo, L. [> > > >]
Laigneau, J. P. [> > > >]
Delwaide, Jean mailto [Centre Hospitalier Universitaire de Liège - CHU > > Gastro-Entérologie-Hépatologie >]
Lewin, M. J. M. [ > > ]
1994
Yale Journal of Biology and Medicine (The)
Yale Journal of Biology and Medicine
67
3-4
113-121
Yes (verified by ORBi)
International
0044-0086
1551-4056
New Haven
CT
[en] Animals ; Blood Vessels/metabolism ; Carbachol/pharmacology ; Dose-Response Relationship, Drug ; Gastrins/secretion ; Histamine Agonists/pharmacology ; Histamine Antagonists/pharmacology ; Male ; Methylhistamines/pharmacology ; Perfusion ; Piperidines/pharmacology ; Rats ; Rats, Wistar ; Receptors, Histamine H3/metabolism ; Somatostatin/secretion ; Stomach/blood supply/metabolism
[en] We have studied the effects of the H3-receptor agonist (R) alpha-methylhistamine [(R) alpha-MeHA] and the H3-receptor antagonist thioperamide (Thiop) on basal- and carbachol-stimulated vascular gastrin release (GR) and somatostatin release (SR) by the isolated rat stomach. Carbachol dose-dependently stimulated and inhibited GR and SR, respectively. Maximal stimulation of GR (500 +/- 112 percent of basal; p < .01), and maximal inhibition of SR (-62 +/- 9 percent under basal; p < .01) were obtained with 1 micron carbachol. Neither (R)alpha-MeHA nor Thiop, up to 10 microns, affected GR. However, SR was dose-dependently enhanced by Thiop (25 +/- 8 percent for 10 microns). Carbachol stimulation of GR was strongly inhibited by Thiop (30 +/- 7 percent for 100 nM and 73 +/- 14 percent for 1 microgram), whereas it was potentiated by (R)alpha-MeHA. Carbachol inhibition of SR was reversed by Thiop and (R)alpha-MeHA. However, the reversal effect of (R)alpha-MeHA was prevented by the CCKB/gastrin receptor antagonist PD134308. These results support H3-receptor regulation of basal and cholinergically-stimulated GR and SR.
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http://hdl.handle.net/2268/66600

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