Article (Scientific journals)
H3-receptor regulation of vascular gastrin and somatostatin releases by the isolated rat stomach.
Bado, A.; Moizo, L.; Laigneau, J. P. et al.
1994In Yale Journal of Biology and Medicine, 67 (3-4), p. 113-121
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Keywords :
Animals; Blood Vessels/metabolism; Carbachol/pharmacology; Dose-Response Relationship, Drug; Gastrins/secretion; Histamine Agonists/pharmacology; Histamine Antagonists/pharmacology; Male; Methylhistamines/pharmacology; Perfusion; Piperidines/pharmacology; Rats; Rats, Wistar; Receptors, Histamine H3/metabolism; Somatostatin/secretion; Stomach/blood supply/metabolism
Abstract :
[en] We have studied the effects of the H3-receptor agonist (R) alpha-methylhistamine [(R) alpha-MeHA] and the H3-receptor antagonist thioperamide (Thiop) on basal- and carbachol-stimulated vascular gastrin release (GR) and somatostatin release (SR) by the isolated rat stomach. Carbachol dose-dependently stimulated and inhibited GR and SR, respectively. Maximal stimulation of GR (500 +/- 112 percent of basal; p < .01), and maximal inhibition of SR (-62 +/- 9 percent under basal; p < .01) were obtained with 1 micron carbachol. Neither (R)alpha-MeHA nor Thiop, up to 10 microns, affected GR. However, SR was dose-dependently enhanced by Thiop (25 +/- 8 percent for 10 microns). Carbachol stimulation of GR was strongly inhibited by Thiop (30 +/- 7 percent for 100 nM and 73 +/- 14 percent for 1 microgram), whereas it was potentiated by (R)alpha-MeHA. Carbachol inhibition of SR was reversed by Thiop and (R)alpha-MeHA. However, the reversal effect of (R)alpha-MeHA was prevented by the CCKB/gastrin receptor antagonist PD134308. These results support H3-receptor regulation of basal and cholinergically-stimulated GR and SR.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Bado, A.
Moizo, L.
Laigneau, J. P.
Delwaide, Jean ;  Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
Lewin, M. J. M.
Language :
English
Title :
H3-receptor regulation of vascular gastrin and somatostatin releases by the isolated rat stomach.
Publication date :
1994
Journal title :
Yale Journal of Biology and Medicine
ISSN :
0044-0086
eISSN :
1551-4056
Publisher :
Yale Journal of Biology and Medicine, New Haven, United States - Connecticut
Volume :
67
Issue :
3-4
Pages :
113-121
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 20 July 2010

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