Reference : Involvement of the brain histaminergic system in addiction and addiction-related behavio...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/66580
Involvement of the brain histaminergic system in addiction and addiction-related behaviors: a comprehensive review with emphasis on the potential therapeutic use of histaminergic compounds in drug dependence
English
Brabant, Christian mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique >]
Alleva, Livia mailto [Université de Liège - ULg > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér. >]
Quertemont, Etienne mailto [Université de Liège - ULg > Département des sciences cognitives > Psychologie quantitative >]
Tirelli, Ezio mailto [Université de Liège - ULg > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér. >]
2010
Progress in Neurobiology
92
421-441
Yes
International
0555-4047
[en] Histamine ; Addiction ; H3 receptors ; Cocaine ; Dopamine ; Reward
[en] Neurons that produce histamine are exclusively located in the tuberomamillary nucleus of the
posterior hypothalamus and send widespread projections to almost all brain areas. Neuronal
histamine is involved in many physiological and behavioral functions such as arousal, feeding
behavior and learning. Although conflicting data have been published, several studies have
also demonstrated a role of histamine in the psychomotor and rewarding effects of addictive
drugs. Pharmacological and brain lesion experiments initially led to the proposition that the
histaminergic system exerts an inhibitory influence on drug reward processes, opposed to that
of the dopaminergic system. The purpose of this review is to summarize the relevant literature
on this topic and to discuss whether the inhibitory function of histamine on drug reward is
supported by current evidence from published results. Research conducted during the past
decade demonstrated that the ability of many antihistaminic drugs to potentiate addictionrelated
behaviors essentially results from non-specific effects and does not constitute a valid
argument in support of an inhibitory function of histamine on reward processes. The reviewed
findings also indicate that histamine can either stimulate or inhibit the dopamine mesolimbic
system through distinct neuronal mechanisms involving different histamine receptors. Finally,
the hypothesis that the histaminergic system plays an inhibitory role on drug reward appears
to be essentially supported by place conditioning studies that focused on morphine reward.
The present review suggests that the development of drugs capable of activating the histaminergic system may offer promising therapeutic tools for the treatment of opioid
dependence.
Centre de Neurosciences Cognitives et Comportementales
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals
http://hdl.handle.net/2268/66580

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