Reference : Structural investigation of reconstituted high density lipoproteins by scanning tunnelli...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/66460
Structural investigation of reconstituted high density lipoproteins by scanning tunnelling microscopy
English
Culot, C. [ > > ]
Durant, F. [ > > ]
Lazarescu, S. [ > > ]
Thiry, P. A. [ > > ]
Vanloo, B. [ > > ]
Rosseneu, M. Y. [ > > ]
Lins, Laurence mailto [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie moléc. et numér. >]
Brasseur, R. [ > > ]
2004
Applied Surface Science
Elsevier Science
203
151-157
Yes (verified by ORBi)
International
0169-4332
Amsterdam
The Netherlands
[en] Being able to participate in the reverse cholesterol transport (RCT), high density lipoproteins (HDL) are known to be anti-atherogenic. In order to understand such a process, it is thus essential to have a detailed knowledge of the structure and molecular organisation of HDL.

Reconstituted nascent high density lipoproteins (r-HDL), consisting of synthetic phospholipids together with different apolipoproteins (apo A-I, A-IV and E), were thus analysed by scanning tunnelling microscopy (STM).

Both shape and dimensions of the discoidal HDL particles measured by this technique were found in good agreement with the data available from the literature.

The accuracy of the STM pictures presented in this paper enables for the first time the visualisation of the molecular organisation of such macromolecules. The arrangement of the protein as antiparallel helical segments, is consistent with the general mode of organisation of apolipoprotein/phospholipid discoidal particles previously reported.
Researchers ; Professionals
http://hdl.handle.net/2268/66460
10.1016/j.apsusc.2004.02.064

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