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Article (Scientific journals)
Post-operative erythropoiesis is limited by the inflammatory effect of surgery on iron metabolism.
Biesma, D. H.; Van de Wiel, A.; Beguin, Yves et al.
1995In European Journal of Clinical Investigation, 25 (6), p. 383-9
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Keywords :
Aged; Anemia/etiology/therapy; Erythrocyte Transfusion; Erythropoiesis; Female; Humans; Inflammation/metabolism; Iron/administration & dosage/metabolism; Male; Middle Aged; Postoperative Complications/etiology/therapy
Abstract :
[en] The decrease in haemoglobin concentration commonly observed after major surgery is usually corrected by red cell transfusions or oral iron medication. The increased awareness of blood-transmissible diseases has led to the restrictive use of homologous blood and to interest in alternatives for correcting anaemia. We investigated the pathophysiology of postoperative anaemia by studying variables of erythropoiesis, iron metabolism, and inflammation in 48 consecutive patients who underwent total hip replacement. Haemoglobin concentration remained low during 14 days after surgery with only a mild increase in erythropoietin concentration and reticulocyte count. No increase in serum transferrin receptor concentration was observed during the first 2 weeks after surgery. Postoperative serum ferritin increased, whereas serum iron, transferrin and transferrin saturation decreased significantly. There was a marked increase in interleukin-6 and C-reactive protein with maximal values on the 1st and 4th post-operative day, respectively. At 6 weeks after surgery, haemoglobin concentration and variables of iron metabolism were almost at the preoperative level and serum transferrin receptor concentration was significantly increased, indicating increased erythropoietic activity. These changes were preceded by the normalization of interleukin-6 and C-reactive protein levels. Haemoglobin, iron, transferrin, and ferritin concentrations were not influenced by iron therapy during the postoperative period and no differences of erythropoietic and iron variables were observed between transfused and non-transfused patients. In conclusion, post-operative erythropoiesis is associated with an inflammatory effect of surgery on iron metabolism, which can explain, despite a slightly increased production of erythropoietin, the persistence of anaemia and the lack of effect of iron supplementation after surgery.
Disciplines :
Hematology
Author, co-author :
Biesma, D. H.
Van de Wiel, A.
Beguin, Yves  ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Kraaijenhagen, Rob J.
Marx, J. J.
Language :
English
Title :
Post-operative erythropoiesis is limited by the inflammatory effect of surgery on iron metabolism.
Publication date :
1995
Journal title :
European Journal of Clinical Investigation
ISSN :
0014-2972
eISSN :
1365-2362
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Volume :
25
Issue :
6
Pages :
383-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 February 2009

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