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Spontaneous complete remission and recovery of donor haemopoiesis without GVHD after relapse and apparent marrow graft rejection in poor-prognosis myelodysplastic syndrome.
Beguin, Yves; Collignon, Jacques; Laurent, C. et al.
1996In British Journal of Haematology, 94 (3), p. 507-9
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Keywords :
Adult; Antiviral Agents/therapeutic use; Bone Marrow Transplantation/methods; Cytomegalovirus Infections/complications/drug therapy; Female; Ganciclovir/therapeutic use; Graft Rejection; Graft vs Host Disease/etiology; Hematopoiesis; Humans; Leukemia, Myelomonocytic, Chronic/complications/therapy; Male; Myelodysplastic Syndromes/blood; Recurrence
Abstract :
[en] We report a patient with poor-prognosis myelodysplastic syndrome (MDS) after successful treatment of lymphoma, who was given an allogeneic BMT, engrafted and achieved complete remission, but later had a relapse of his MDS with complete disappearance of donor haemopoiesis. After two episodes of CMV pneumonia and continued prophylactic use of ganciclovir thereafter, he experienced a spontaneous complete disappearance of all signs of MDS, including myelofibrosis, and a complete return to donor haemopoiesis. This case is the first one to suggest a graft-versus-leukaemia effect (GVL) in MDS patients. It depicts the complex relationship between GVL, graft-versus-host disease (GVHD) and graft rejection. It could also constitute a clinical illustration of the possible antileukaemic effect of CMV infection and its treatment with ganciclovir.
Disciplines :
Hematology
Author, co-author :
Beguin, Yves  ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Collignon, Jacques ;  Centre Hospitalier Universitaire de Liège - CHU > Imagerie médicale
Laurent, C.
Fillet, Georges ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Language :
English
Title :
Spontaneous complete remission and recovery of donor haemopoiesis without GVHD after relapse and apparent marrow graft rejection in poor-prognosis myelodysplastic syndrome.
Publication date :
1996
Journal title :
British Journal of Haematology
ISSN :
0007-1048
eISSN :
1365-2141
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Volume :
94
Issue :
3
Pages :
507-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 February 2009

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