Reference : L'extrapolation des bioréacteurs : un problème de génie des procédés ou de physiologie m...
Scientific journals : Article
Life sciences : Biotechnology
http://hdl.handle.net/2268/66185
L'extrapolation des bioréacteurs : un problème de génie des procédés ou de physiologie microbienne ?
English
Delvigne, Frank mailto [Université de Liège - ULg > Chimie et bio-industries > Bio-industries >]
Destain, Jacqueline mailto [Université de Liège - ULg > Chimie et bio-industries > Bio-industries >]
Brognaux, Alison mailto [Université de Liège - ULg > Chimie et bio-industries > Bio-industries >]
Kar, Tambi mailto [Université de Liège - ULg > > > Doct. sc. agro. & ingé. biol.]
Lejeune, Annick mailto [Université de Liège - ULg > Chimie et bio-industries > Bio-industries >]
Thonart, Philippe mailto [Université de Liège - ULg > Département des sciences de la vie > Biochimie et microbiologie industrielles - Bio-industries >]
2010
Chimie Nouvelle
Société Royale de Chimie
104
7-14
No
National
0771-730X
Bruxelles
Belgium
[en] Bioreactor scale-up often pose a serious issue during the industrial development of a bioprocess considering the numerous physical and biological phenomena occurring in the reacting volume. The basic principles of scale-up coming from the traditional chemical and process engineering approaches will be first reviewed and will be then compared to a new one involving recent development at the level of microbial strain manipulation. This "physiological" approach of scale-up involves directly a biological component of the system (by comparison with the traditional approach for scaling-up involving physical parameters indirectly linked to the physiological phenomena occurring in the bioreactor), i.e. the synthesis of a reporter fluorescent protein when microbial cells are exposed to stress. It will be shown how this principle can be used for a better understanding of the relationship between bioreactor hydrodynamics and microbial stress.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/66185

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