Article (Scientific journals)
In vitro antiplasmodial activity of Tithonia diversifolia and identification of its main active constituent: tagitinin C.
Goffin, Eric; Ziemons, Eric; De Mol, Patrick et al.
2002In Planta Medica, 68 (6), p. 543-5
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Keywords :
Animals; Antimalarials/pharmacology; Asteraceae; Chloroquine/pharmacology; Humans; Inhibitory Concentration 50; Plant Extracts/pharmacology; Plasmodium falciparum/drug effects; Sesquiterpenes/chemistry/isolation & purification/pharmacology; Tumor Cells, Cultured
Abstract :
[en] The antimalarial properties of Tithonia diversifolia, an Asteraceae traditionally used to treat malaria, were investigated in vitro against three strains of Plasmodium falciparum. The ether extract from aerial parts of the plant collected in Sao Tome e Principe, demonstrated good antiplasmodial activity (IC 50 on FCA strain: 0.75 microg/ml). A bioassay guided fractionation of this extract led to the isolation of the known sesquiterpene lactone tagitinin C as an active component against Plasmodium (IC 50 on FCA strain: 0.33 microg/ml), but also possessing cytotoxic properties (IC 50 on HTC-116 cells: 0.706 microg/ml).
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Goffin, Eric ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Ziemons, Eric  ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
De Mol, Patrick ;  Centre Hospitalier Universitaire de Liège - CHU > Microbiologie médicale
de Madureira, Maria do Ceu;  University of Coimbra - UC > Faculty of Pharmacy > Laboratory of Pharmacognosy
Martins, Ana Paula;  University of Coimbra - UC > Faculty of Pharmacy > Laboratory of Pharmacognosy
da Cunha, Antonio Proenca;  University of Coimbra - UC > Faculty of Pharmacy > Laboratory of Pharmacognosy
Philippe, Geneviève  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Tits, Monique ;  Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie
Angenot, Luc  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Frederich, Michel  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
English
Title :
In vitro antiplasmodial activity of Tithonia diversifolia and identification of its main active constituent: tagitinin C.
Publication date :
June 2002
Journal title :
Planta Medica
ISSN :
0032-0943
eISSN :
1439-0221
Publisher :
Georg Thieme Verlag Stuttgart, New York, United States - New York
Volume :
68
Issue :
6
Pages :
543-5
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 February 2009

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