Reference : In vitro antiplasmodial activity of Tithonia diversifolia and identification of its main...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/6563
In vitro antiplasmodial activity of Tithonia diversifolia and identification of its main active constituent: tagitinin C.
English
Goffin, Eric mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie > >]
Ziemons, Eric mailto [Université de Liège - ULg > Département de pharmacie > Chimie analytique >]
De Mol, Patrick mailto [Centre Hospitalier Universitaire de Liège - CHU > > Microbiologie médicale >]
de Madureira, Maria do Ceu [University of Coimbra - UC > Faculty of Pharmacy > Laboratory of Pharmacognosy > >]
Martins, Ana Paula [University of Coimbra - UC > Faculty of Pharmacy > Laboratory of Pharmacognosy > >]
da Cunha, Antonio Proenca mailto [University of Coimbra - UC > Faculty of Pharmacy > Laboratory of Pharmacognosy > >]
Philippe, Geneviève mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Tits, Monique mailto [Université de Liège - ULg > Département de pharmacie > Phytochimie et phytothérapie >]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Frederich, Michel mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Jun-2002
Planta Medica
Georg Thieme Verlag Stuttgart
68
6
543-5
Yes (verified by ORBi)
International
0032-0943
New York
NY
[en] Animals ; Antimalarials/pharmacology ; Asteraceae ; Chloroquine/pharmacology ; Humans ; Inhibitory Concentration 50 ; Plant Extracts/pharmacology ; Plasmodium falciparum/drug effects ; Sesquiterpenes/chemistry/isolation & purification/pharmacology ; Tumor Cells, Cultured
[en] The antimalarial properties of Tithonia diversifolia, an Asteraceae traditionally used to treat malaria, were investigated in vitro against three strains of Plasmodium falciparum. The ether extract from aerial parts of the plant collected in Sao Tome e Principe, demonstrated good antiplasmodial activity (IC 50 on FCA strain: 0.75 microg/ml). A bioassay guided fractionation of this extract led to the isolation of the known sesquiterpene lactone tagitinin C as an active component against Plasmodium (IC 50 on FCA strain: 0.33 microg/ml), but also possessing cytotoxic properties (IC 50 on HTC-116 cells: 0.706 microg/ml).
Researchers
http://hdl.handle.net/2268/6563
10.1055/s-2002-32552

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