Reference : Equine gammaherpesviruses : pathogenesis, epidemiology and diagnosis
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
Life sciences : Microbiology
http://hdl.handle.net/2268/65367
Equine gammaherpesviruses : pathogenesis, epidemiology and diagnosis
English
Fortier, Guillaume [Frank Duncombe Laboratory, Caen cedex 4, France > > > >]
Van Erck, Emmanuelle [Université de Liège - ULg > Département clinique des animaux de production (DCP) > Département clinique des animaux de production (DCP) >]
Pronost, Stéphane [Frank Duncombe Laboratory, Caen cedex 4, France > > > >]
Lekeux, Pierre mailto [Université de Liège - ULg > Département de sciences fonctionnelles > Physiologie - Doyen de la Faculté de Médecine vétérinaire >]
Thiry, Etienne mailto [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Virologie, épidémiologie et pathologie des maladies virales >]
2010
Veterinary Journal
Elsevier
186
148-156
Yes (verified by ORBi)
International
1090-0233
[en] Horse ; Gammaherpesvirus ; EHV-2 ; EHV-5 ; Pathogenesis ; Epidemiology ; Equine herpesvirus
[en] Equine gammaherpesviruses (cEHV) have been widely studied over the past 45 years and many isolates have been characterised. Despite this, the diagnosis of cEHV infection remains difficult to establish as its clinical manifestations lack specificity, ranging from mild respiratory signs in a small number of animals to outbreaks in large groups of young horses. This review focuses on the epidemiology, pathogenesis, clinical manifestations and diagnosis of equine herpesvirus (EHV)-2 and -5 infections, as well as on the genetic variation of these viruses. Study of these variations has resulted in hypotheses relating to viral re-infection and re-activation. Interestingly, the viruses were found to contain genetic sequences identical to those of eukaryotic cells which are considered central to the development of viral latency through interfering with host immune and inflammatory responses. Future molecular biological studies will further elucidate the virulence mechanisms of these equine pathogens
Researchers ; Professionals
http://hdl.handle.net/2268/65367

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