Reference : A type II-collagen derived peptide and its nitrated form as new markers of inflammati...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/64664
A type II-collagen derived peptide and its nitrated form as new markers of inflammation and cartilage degradation in equine osteochondral lesions.
English
Gangl, Monika mailto [Ecole Nationale Vétérinaire de Lyon, France. > Département Hippique > > >]
Deberg, Michelle mailto [Université de Liège - ULg > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.) >]
Lejeune, Jean-Philippe mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux >]
Schneider, Nicole mailto [Université de Liège - ULg > European Horse Center, Mont-le-Soie, Vielsalm, Belgium > > >]
Grulke, Sigrid mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés >]
Peters, Fabrice [ > > ]
Vila, T. [ > > ]
Deby-Dupont, Ginette [ > > ]
Serteyn, Didier mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux >]
Henrotin, Yves mailto [Université de Liège - ULg > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.) - Didactique des sciences de la santé - Pathologie générale et physiopathologie >]
2007
Research in Veterinary Science
British Veterinary Association
82
68-75
Yes (verified by ORBi)
International
0034-5288
London
United Kingdom
[en] type II collagen ; cartilage ; horse ; nitration ; osteochondrosis ; equine
[en] Markers of cartilage breakdown enable studying the degradation of cartilage matrix in equine joint pathologies. This study was designed to determine the levels of Coll2-1, a peptide of the triple helix of type II collagen, and Coll2-1NO(2), its nitrated form in the plasma of healthy horses (controls; n=37) and horses suffering from osteochondrosis (n=34). Clinical and arthroscopic scores were attributed reflecting the severity of lesions and were related to the plasma levels of Coll2-1 and Coll2-1NO(2). The median of Coll2-1 was significantly higher in the control group, whereas the mean of Coll2-1NO(2) showed significant elevation in the pathological group. However, the measurement means of scoring classes did not vary significantly. The markers were able to differentiate the group of horses suffering from osteochondrosis from the group of healthy horses. The elevation of Coll2-1NO(2) in the pathological group indicates an inflammation, mediated through reactive oxygen species and/or increased myeloperoxidase activity.
Department of Clinical Sciences, Large Animal Surgery, Faculty of Veterinary Medicine, University of Liège, Sart Tilman B41, B-4000 Liège, Belgium ; Bone and Cartilage Research Unit, University of Liège, Belgium ; Center for Oxygen Research and Development, University of Liège, Belgium ; European Horse Center, Mont-le-Soie, Vielsalm, Belgium ; Clinique Vétérinaire Equine, Chantilly, France
Researchers ; Professionals
http://hdl.handle.net/2268/64664
10.1016/j.rvsc.2006.03.008
http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WWR-4K606P0-1-3&_cdi=7137&_user=9420350&_pii=S0034528806000798&_orig=search&_coverDate=02%2F28%2F2007&_sk=999179998&view=c&wchp=dGLbVlz-zSkzk&md5=6eb7e52d92596c3759313571be0005f6&ie=/sdarticle.pdf

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