Article (Scientific journals)
Cyclosporine a Inhibits Partially Spermine-Induced Differentiation but Not Cell Loss of Suckling Rat Small Intestine
Peulen, Olivier; Dandrifosse, Guy
2000In Digestive Diseases and Sciences, 45 (4), p. 750-4
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Abstract :
[en] The polyamines are of great importance in several biological processes, such as cell proliferation, and differentiation. The ingestion of spermine by suckling rats induces the precocious maturation of their small intestine. This phenomenon is preceded by a cell elimination at the villus tip. We hypothesize that these two phenomena could be mediated by the immune system and thus inhibited by an immunosuppressive agent such as cyclosporine A. Cyclosporine A inhibits, at least partially, the spermine-induced increase of the maltase- and sucrase-specific activities in the small intestine but failed to inhibit lactase-specific activity decrease and cell loss. Spermine does not act by the same mechanism in differentiation and in cell loss. Moreover, spermine acts in a different way on lactase-specific activity compared to maltase- or sucrase-specific activity. We hypothesize that spermine acts on differentiation by a T-cell/IL-2-dependent mechanism.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Peulen, Olivier  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Dandrifosse, Guy ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
Cyclosporine a Inhibits Partially Spermine-Induced Differentiation but Not Cell Loss of Suckling Rat Small Intestine
Publication date :
April 2000
Journal title :
Digestive Diseases and Sciences
ISSN :
0163-2116
eISSN :
1573-2568
Publisher :
Kluwer Academic/Plenum Publishers, United States - New York
Volume :
45
Issue :
4
Pages :
750-4
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
The original publication is available at www.springerlink.com.
Available on ORBi :
since 30 June 2010

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