Article (Scientific journals)
Potential antimalarial activity of indole alkaloids
Frederich, Michel; Tits, Monique; Angenot, Luc
2008In Transactions of the Royal Society of Tropical Medicine and Hygiene, 102 (1), p. 11-19
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Abstract :
[en] New antimalarial treatments are now urgently required, following the emergence of resistance to the most used drugs. Natural products contribute greatly to the therapeutic arsenal in this area, including artemisinin and quinine (and atovaquone, semi-synthetic). Among the natural products, indole alkaloids represent an interesting class of compounds. Screening carried out to date has revealed several substances active in vitro under the micromolar range and with a good selectivity index. This review covers the indole alkaloids with high antiplasmodial activity (in vitro and in vivo) isolated from natural sources, and is organized according to the different chemical structures of the alkaloids.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Frederich, Michel  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Tits, Monique ;  Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie
Angenot, Luc  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
English
Title :
Potential antimalarial activity of indole alkaloids
Publication date :
January 2008
Journal title :
Transactions of the Royal Society of Tropical Medicine and Hygiene
ISSN :
0035-9203
Publisher :
Royal Society of Tropical Medicine and Hygiene, United Kingdom
Volume :
102
Issue :
1
Pages :
11-19
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 30 September 2008

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