Reference : The Erythrocyte/Brain Glucose Transporter (Glut1) May Adopt A Two-Channel Transmembra...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
The Erythrocyte/Brain Glucose Transporter (Glut1) May Adopt A Two-Channel Transmembrane Alpha/Beta Structure.
Ducarme, P. [> > > >]
Rahman, M. [> > > >]
Lins, Laurence mailto [Université de Liège - ULg > > Gembloux Agro-Bio Tech >]
Brasseur, Robert mailto [Université de Liège - ULg > > Gembloux Agro-Bio Tech >]
Journal of Molecular Modeling
Yes (verified by ORBi)
[en] There are two models of topology for the membrane domains of the erythrocyte/brain facilitative glucose transporter, GLUT1. The first is composed of 12 membrane-spanning a-helices, the second of 16 membrane-spanning b-strands. We have used Jähnig’s and Eisenberg’s methods to identify possible transmembrane segments (10 spanning a-helices and 4 b-strands). The topology proposed is more consistent with available experimental
data from FTIR, CD and mapping experiment than the previous models . We suggest that GLUT1 might form two channels, one of which is responsible for glucose transport. This agrees with the theoretical and experimental arguments. Finally, an analysis of the mutation periodicity and of the mean hydrophobicity for the GLUT family is provided in order to evaluate the packing of the protein in the membrane.
Researchers ; Professionals

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