Reference : The Erythrocyte/Brain Glucose Transporter (Glut1) May Adopt A Two-Channel Transmembrane ...

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/64323

Title :	The Erythrocyte/Brain Glucose Transporter (Glut1) May Adopt A Two-Channel Transmembrane Alpha/Beta Structure.
Language :	English
Author, co-author :	Ducarme, P. [> > > >]
	Rahman, M. [> > > >]
	Lins, Laurence [Université de Liège > > Gembloux Agro-Bio Tech >]
	Brasseur, Robert [Université de Liège > > Gembloux Agro-Bio Tech >]
Publication date :	1996
Journal title :	Journal of Molecular Modeling
Volume :	2
Issue/season :	2
Pages :	27-45
Audience :	International
ISSN :	0948-5023
Abstract :	[en] There are two models of topology for the membrane domains of the erythrocyte/brain facilitative glucose transporter, GLUT1. The first is composed of 12 membrane-spanning a-helices, the second of 16 membrane-spanning b-strands. We have used Jähnig’s and Eisenberg’s methods to identify possible transmembrane segments (10 spanning a-helices and 4 b-strands). The topology proposed is more consistent with available experimental data from FTIR, CD and mapping experiment than the previous models . We suggest that GLUT1 might form two channels, one of which is responsible for glucose transport. This agrees with the theoretical and experimental arguments. Finally, an analysis of the mutation periodicity and of the mean hydrophobicity for the GLUT family is provided in order to evaluate the packing of the protein in the membrane. Keywords:
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/64323

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