Reference : Population-level retrospective study of neurologically expressed disorders in ruminants ...
Scientific journals : Article
Life sciences : Microbiology
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/7625
Population-level retrospective study of neurologically expressed disorders in ruminants before the onset of bovine spongiform encephalopathy (BSE) in Belgium, a BSE risk III country.
English
Saegerman, Claude mailto [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Epidémiologie et analyse des risques appl. aux sc. vétér. >]
Berkvens, D. [> > > >]
Claes, L. [> > > >]
Dewaele, A. [> > > >]
Coignoul, Freddy mailto [Université de Liège - ULg > Département de morphologie et pathologie > Pathologie générale et autopsies >]
Ducatelle, R. [> > > >]
Cassart, Dominique mailto [Université de Liège - ULg > Département de morphologie et pathologie > Département de morphologie et pathologie >]
Brochier, B. [> > > >]
Costy, F. [> > > >]
Roels, S. [> > > >]
Deluyker, H. [> > > >]
Vanopdenbosch, E. [> > > >]
Thiry, Etienne mailto [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Virologie, épidémiologie et pathologie des maladies virales >]
2005
Journal of Clinical Microbiology
American Society for Microbiology (ASM)
43
2
862-9
Yes (verified by ORBi)
International
0095-1137
1098-660X
Washington
DC
[en] Animals ; Belgium/epidemiology ; Cattle ; Cattle Diseases/epidemiology/etiology ; Encephalopathy, Bovine Spongiform/epidemiology ; Goat Diseases/epidemiology/etiology ; Goats ; Incidence ; Nervous System Diseases/epidemiology/etiology/veterinary ; Retrospective Studies ; Ruminants ; Sheep ; Sheep Diseases/epidemiology/etiology
[en] A retrospective epidemiological study (n = 7,875) of neurologically expressed disorders (NED) in ruminants before the onset of the bovine spongiform encephalopathy epidemic (years studied, 1980 to 1997) was carried out in Belgium. The archives of all veterinary laboratories and rabies and transmissible spongiform encephalopathy (TSE) epidemiosurveillance networks were consulted. For all species, a significantly higher number of NED with virological causes (rabies) was reported south of the Sambre-Meuse Valley. During the period 1992 to 1997, for which the data were complete, (i) the predicted annual incidence of NED varied significantly as a function of species and area (higher numbers in areas where rabies was present) but was always above 100 cases per million, and (ii) the mean incidence of suspected TSE cases and, among them, those investigated by histopathological examination varied significantly as a function of species and area. The positive predictive value of a presumptive clinical diagnosis of NED ranged from 0.13 (game) to 0.63 (sheep). Knowledge of the positive predictive value permits the definition of a reference point before certain actions (e.g., awareness and training campaigns) are undertaken. It also shows the usefulness of a systematic necropsy or complementary laboratory tests to establish an etiological diagnosis. TSE analysis of a small, targeted historical sampling (n = 48) permitted the confirmation of one case and uncovered another case of scrapie. The results of the present study help to develop and maintain the quality of the worldwide clinical epidemiological networks for TSE, especially in countries that in the past imported live animals, animal products, and feedstuffs from countries with TSE cases.
http://hdl.handle.net/2268/7625
also: http://hdl.handle.net/2268/64070
10.1128/JCM.43.2.862-869.2005

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