[en] Memory consolidation benefits from sleep. Besides strengthening some memory traces, another crucial, albeit overlooked, function of memory is also to erase irrelevant information. Directed forgetting is an experimental approach consisting in presenting “to be remembered” and “to be forgotten” information, that allows selectively decreasing or increasing the strength of individual memory traces according to the instruction provided at learning. This paradigm was used in combination with fMRI to determine, in Humans, what specifically triggers at encoding sleep-dependent compared to time-dependent consolidation. Our data indicate that relevant items which subjects strived to memorize are consolidated during sleep to a greater extend than items that participants did not intend to learn. This process appears to depend on a differential activation of the hippocampus at encoding, which acts as a signal for the offline reprocessing of relevant memories during post-learning sleep episodes.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Rauchs, Géraldine
Feyers, Dorothée ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Landeau, Brigitte
Bastin, Christine ; Université de Liège - ULiège > Centre de recherches du cyclotron
Luxen, André ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron
Maquet, Pierre ; Université de Liège - ULiège > Centre de recherches du cyclotron - Département des sciences cliniques
Collette, Fabienne ; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie
Language :
English
Title :
Sleep contributes to the strengthening of some memories over others, depending on hippocampal activity at learning.
Publication date :
2011
Journal title :
Journal of Neuroscience
ISSN :
0270-6474
eISSN :
1529-2401
Publisher :
Society for Neuroscience, Washington, United States - District of Columbia
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