Reference : Insulinotropic action of (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propiona...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/63800
Insulinotropic action of (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate. II. Ionophoretic and conformational aspects.
English
Malaisse, W. J. [> > > >]
Nadi, A. B. [> > > >]
Malaisse-Lagae, F. [> > > >]
Sato, F. [> > > >]
Lins, Laurence mailto [Université de Liège - ULg > > Gembloux Agro-Bio Tech >]
Brasseur, Robert mailto [Université de Liège - ULg > > Gembloux Agro-Bio Tech >]
1995
General Pharmacology
Elsevier Science
26
6
1319-25
Yes (verified by ORBi)
International
0306-3623
Exeter
United Kingdom
[en] Animals ; Calcium/metabolism/pharmacology ; Cations/metabolism ; Hypoglycemic Agents/chemistry/pharmacology ; Indoles/chemistry/pharmacology ; Ionophores ; Isoindoles ; Models, Molecular ; Molecular Structure ; Rats
[en] 1. The non-sulphonylurea insulinotropic agent sodium (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) was found to display calcium ionophoretic activity in an artificial membrane model. 2. Conformation analysis indicated that a complex between calcium and KAD-1229, with a 1:2 stoichiometry, indeed displays favourable attributes for ionophoretic activity across a hydrophobic environment. 3. It is speculated that the ionophoretic property of KAD-1229 might participate to the remodelling of cationic fluxes evoked by this insulinotropic agent in pancreatic islet cells.
Researchers ; Professionals
http://hdl.handle.net/2268/63800

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