Reference : Conformational-Analysis Of The Calcium Complexes Formed By Meglitinide Analogs
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Conformational-Analysis Of The Calcium Complexes Formed By Meglitinide Analogs
Lins, Laurence mailto [Université de Liège > > Gembloux Agro-Bio Tech >]
Brasseur, Robert mailto [Université de Liège > > Gembloux Agro-Bio Tech >]
Malaisse, Wj. [> > > >]
Research Communications In Molecular Pathology and Pharmacology
Yes (verified by ORBi)
[en] The conformation of calcium complexes formed with meglitinide and its
hypoglycemic analogs KAD-1229, A-4166, S 3075 and repaglinide was analyzed by a
semi-empirical procedure, which includes calculation of the molecular
hydrophobicity potential. The calcium complexes formed with KAD-1229, A-4166,
repaglinide or its enantiomer, displayed favourable attributes to act as
ionophores. Such was not the case for the poorly efficient insulinotropic agent
meglitinide and the biologically inactive enantiomer of A-4166. The configuration
of the calcium complex formed with S 3075 also failed to display the features
required for a high ionophoretic capacity.
Researchers ; Professionals

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