Reference : Conformational-Analysis Of The Calcium Complexes Formed By Meglitinide Analogs

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/63769

Title :	Conformational-Analysis Of The Calcium Complexes Formed By Meglitinide Analogs
Language :	English
Author, co-author :	Lins, Laurence [Université de Liège > > Gembloux Agro-Bio Tech >]
	Brasseur, Robert [Université de Liège > > Gembloux Agro-Bio Tech >]
	Malaisse, Wj. [> > > >]
Publication date :	1995
Journal title :	Research Communications In Molecular Pathology and Pharmacology
Volume :	90
Issue/season :	1
Pages :	153-64
Audience :	International
ISSN :	1078-0297
Abstract :	[en] The conformation of calcium complexes formed with meglitinide and its hypoglycemic analogs KAD-1229, A-4166, S 3075 and repaglinide was analyzed by a semi-empirical procedure, which includes calculation of the molecular hydrophobicity potential. The calcium complexes formed with KAD-1229, A-4166, repaglinide or its enantiomer, displayed favourable attributes to act as ionophores. Such was not the case for the poorly efficient insulinotropic agent meglitinide and the biologically inactive enantiomer of A-4166. The configuration of the calcium complex formed with S 3075 also failed to display the features required for a high ionophoretic capacity.
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/63769

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