Bage - A New Gene Encoding An Antigen Recognized On Human Melanomas By Cytolytic T-Lymphocytes

[en] Several tumor antigens are recognized by autologous cytolytic T lymphocytes (CTL) on human melanoma MZ2-MEL. Some of them are encoded by genes MAGE-1 and MAGE-3, which are not expressed in normal tissues except in testis. Here, we report the identification of a new gene that codes for another of these antigens. This gene, named BAGE, codes for a putative protein of 43 aa and seems to belong to a family of several genes. The antigen recognized by the autologous CTL consists of BAGE-encoded peptide AARAVFLAL bound to an HLA-Cw 1601 molecule. Gene BAGE is expressed in 22% of melanomas, 30% of infiltrating bladder carcinomas, 10% of mammary carcinomas, 8% of head and neck squamous cell carcinomas, and 6% of non-small cell lung carcinomas. Like the MAGE genes, it is silent in normal tissues with the exception of testis. Because of its tumor-specific expression, the BAGE-encoded antigen may prove useful for cancer immunotherapy.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Boel, P.

Wildmann, C.

Sensi, Ml.

Brasseur, Robert ; Université de Liège - ULiège > Gembloux Agro-Bio Tech

Renauld, Jc.

Coulie, P.

Boon, T.

Vanderbruggen, P.

Language :

English

Title :

Bage - A New Gene Encoding An Antigen Recognized On Human Melanomas By Cytolytic T-Lymphocytes

Publication date :

1995

Journal title :

Immunity

ISSN :

1074-7613

eISSN :

1097-4180

Publisher :

Cell Press, United States - Massachusetts

Volume :

Issue :

Pages :

167-175
167-75

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 25 June 2010

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5 (5 by ULiège)

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Scopus citations^®

568

Scopus citations^®
without self-citations

511

OpenCitations

407

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