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| Reference : Pharmacology Of The Hypoglycaemic Sulphonylurea Gliquidone .3. Conformational Analysis |
| Scientific journals : Article | |||
| Life sciences : Biochemistry, biophysics & molecular biology | |||
| http://hdl.handle.net/2268/63747 | |||
| Pharmacology Of The Hypoglycaemic Sulphonylurea Gliquidone .3. Conformational Analysis | |
| English | |
Lins, Laurence  [Université de Liège > > Gembloux Agro-Bio Tech >] | |
| Brasseur, Robert [Université de Liège > > Gembloux Agro-Bio Tech >] | |
| Malaisse, Wj. [> > > >] | |
| 1996 | |
| Pharmacological Research | |
| 34 | |
| 1-2 | |
| 9-10 | |
| International | |
| 1043-6618 | |
| [en] The hypoglycaemic sulphonylurea gliquidone was found, by conformation analysis,
to display a U-shaped configuration, with hydrophobic cycles placed at the extremity of each branch and a peptidic bond placed at the bottom of the U. This configuration is similar to that recently observed with the hypoglycaemic sulphonylureas glimepiride and glibenclamide and non-sulphonylurea hypoglycaemic agents of the meglitinide family, such as S3075, repaglinide, A-4166 and KAD-1229. The identification of a conformation common to these various hypoglycaemic drugs may provide an imprint of their binding site at the level of the B-cell sulphonylurea receptor. | |
| Researchers ; Professionals | |
| http://hdl.handle.net/2268/63747 |
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