Pharmacology Of The Hypoglycaemic Sulphonylurea Gliquidone .3. Conformational Analysis

The hypoglycaemic sulphonylurea gliquidone was found, by conformation analysis,
to display a U-shaped configuration, with hydrophobic cycles placed at the
extremity of each branch and a peptidic bond placed at the bottom of the U. This
configuration is similar to that recently observed with the hypoglycaemic
sulphonylureas glimepiride and glibenclamide and non-sulphonylurea hypoglycaemic
agents of the meglitinide family, such as S3075, repaglinide, A-4166 and
KAD-1229. The identification of a conformation common to these various
hypoglycaemic drugs may provide an imprint of their binding site at the level of
the B-cell sulphonylurea receptor.