Reference : Pharmacology Of The Hypoglycaemic Sulphonylurea Gliquidone .3. Conformational Analysis
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/63747
Pharmacology Of The Hypoglycaemic Sulphonylurea Gliquidone .3. Conformational Analysis
English
Lins, Laurence mailto [Université de Liège > > Gembloux Agro-Bio Tech >]
Brasseur, Robert mailto [Université de Liège > > Gembloux Agro-Bio Tech >]
Malaisse, Wj. [> > > >]
1996
Pharmacological Research
34
1-2
9-10
Yes (verified by ORBi)
International
1043-6618
[en] The hypoglycaemic sulphonylurea gliquidone was found, by conformation analysis,
to display a U-shaped configuration, with hydrophobic cycles placed at the
extremity of each branch and a peptidic bond placed at the bottom of the U. This
configuration is similar to that recently observed with the hypoglycaemic
sulphonylureas glimepiride and glibenclamide and non-sulphonylurea hypoglycaemic
agents of the meglitinide family, such as S3075, repaglinide, A-4166 and
KAD-1229. The identification of a conformation common to these various
hypoglycaemic drugs may provide an imprint of their binding site at the level of
the B-cell sulphonylurea receptor.
Researchers ; Professionals
http://hdl.handle.net/2268/63747

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