Reference : Tilted Peptides: A Motif For Membrane Destabilization (Hypothesis)
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/63670
Tilted Peptides: A Motif For Membrane Destabilization (Hypothesis)
English
Brasseur, Robert mailto [Université de Liège > > Gembloux Agro-Bio Tech >]
2000
Molecular Membrane Biology
17
1
31-40
Yes (verified by ORBi)
0968-7688
[en] Cell life depends on the dynamics of molecular processes: molecule folding,
organelle building and transformations involving membrane fusion, protein
activation and degradation. To carry out these processes, the
hydrophilic/hydrophobic interfaces of amphipathic systems such as membranes and
native proteins must be disrupted. In the past decade, protein fragments acting
in the disruption of interfaces have been evidenced: they are named the tilted or
oblique peptides. Due to a peculiar distribution of hydrophobicity, they can
disrupt hydrophobicity interfaces. Tilted peptides should be present in many
proteins involved in various stages of cell life. This hypothesis overviews their
discovery, describes how they are detected and discusses how they could be
involved in dynamic biological processes.
Researchers ; Professionals
http://hdl.handle.net/2268/63670

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