Reference : Morphological Changes of Thymus in Retrovirus-Induced Murine Acquired Immunodeficiency S...
Scientific journals : Article
Human health sciences : Immunology & infectious disease
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
http://hdl.handle.net/2268/63625
Morphological Changes of Thymus in Retrovirus-Induced Murine Acquired Immunodeficiency Syndrome (Maids)
English
de Leval, Laurence mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Deprez, Manuel [Université de Liège - ULg > Département des sciences cliniques > Neuropathologie >]
Colombi, S. [> > > >]
Humblet, Chantal mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
Defresne, Marie-Paule mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
Boniver, Jacques mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques]
Moutschen, Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Immunopathologie - Transplantation]
1995
Pathology - Research & Practice
Gustav Fischer Verlag
191
6
506-12
Yes (verified by ORBi)
International
0344-0338
Stuttgart
Germany
[en] Animals ; Atrophy/pathology ; Disease Models, Animal ; Male ; Mice ; Mice, Inbred C57BL ; Murine Acquired Immunodeficiency Syndrome/pathology ; Organ Size ; Retroviridae ; Time Factors ; Thymus Gland/pathology
[en] The possible contribution of the thymus in the setting of acquired immunodeficiencies is still questioned. Here we report some new findings regarding a potential involvement of the thymus in mice infected with RadLV-Rs, a viral mixture inducing murine acquired immunodeficiency syndrome (MAIDS). Thymi were sequentially removed, weighted and morphologically analyzed at different time intervals post-infection. Infection with RadLV-Rs led to a decrease in thymus weight mostly apparent from the fourth week. The first changes were seen at the third week as perivascular clusters of B-cells at the cortico-medullary junction. The ensuing process of atrophy mainly involved the cortex, while a mixed population of large T- and B-cells filled the medulla. These observations are discussed with regard to the pathological changes occurring in other lymphoid and non-lymphoid organs, in the context of the lymphoproliferation and immunodeficiency characterizing the disease, and by comparison with other models of retrovirus-induced immunodeficiencies.
Researchers ; Professionals
http://hdl.handle.net/2268/63625
also: http://hdl.handle.net/2268/75656 ; http://hdl.handle.net/2268/64381

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