Reference : Chrysopentamine, an antiplasmodial anhydronium base from Strychnos usambarensis leaves
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
Physical, chemical, mathematical & earth Sciences : Chemistry
Life sciences : Phytobiology (plant sciences, forestry, mycology...)
http://hdl.handle.net/2268/6361
Chrysopentamine, an antiplasmodial anhydronium base from Strychnos usambarensis leaves
English
Frederich, Michel mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Cristino, Assunção [> > > >]
Choi, Young Hae [> > > >]
Verpoorte, Robert [> > > >]
Tits, Monique mailto [Université de Liège - ULg > Département de pharmacie > Phytochimie et phytothérapie >]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Prost, Elise [> > > >]
Nuzillard, Jean-Marc [> > > >]
Zèches-Hanrot, Monique [> > > >]
Jan-2004
Planta Medica
Georg Thieme Verlag Kg
70
1
72-76
Yes (verified by ORBi)
International
0032-0943
Stuttgart
[en] antiplasmodial activity ; Strychnos ; Plasmodium falciparum ; indole alkaloid ; indolomonoterpenoid
[en] A new derivative of strychnopentamine was isolated from the leaves of Strychnos usambarensis. This compound, named chrysopentamine, was identified by detailed spectroscopic methods (UV, IR, HR-ESI-MS, 1D and 2D NMR). Chrysopentamine presented an original hydroxy substitution on C-14 and an aromatization of the ring D of strychnopentamine leading to anhydronium base proper-ties and exhibited strong antiplasmodial properties (IC50 less than 1 muM).
http://hdl.handle.net/2268/6361

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