ORBi: Frederich Michel - Chrysopentamine, an antiplasmodial anhydronium base from Strychnos usambarensis leaves

Reference : Chrysopentamine, an antiplasmodial anhydronium base from Strychnos usambarensis leaves


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Pharmacy, pharmacology & toxicology Physical, chemical, mathematical & earth Sciences : Chemistry Life sciences : Phytobiology (plant sciences, forestry, mycology...)
	To cite this reference:	http://hdl.handle.net/2268/6361

Title :	Chrysopentamine, an antiplasmodial anhydronium base from Strychnos usambarensis leaves
Language :	English
Author, co-author :	Frederich, Michel [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
	Cristino, Assunção [> > > >]
	Choi, Young Hae [> > > >]
	Verpoorte, Robert [> > > >]
	Tits, Monique [Université de Liège - ULg > Département de pharmacie > Phytochimie et phytothérapie >]
	Angenot, Luc [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
	Prost, Elise [> > > >]
	Nuzillard, Jean-Marc [> > > >]
	Zèches-Hanrot, Monique [> > > >]
Publication date :	Jan-2004
Journal title :	Planta Medica
Publisher :	Georg Thieme Verlag Kg
Volume :	70
Issue/season :	1
Pages :	72-76
Audience :	International
ISSN :	0032-0943
City :	Stuttgart
Keywords :	[en] antiplasmodial activity ; Strychnos ; Plasmodium falciparum ; indole alkaloid ; indolomonoterpenoid
Abstract :	[en] A new derivative of strychnopentamine was isolated from the leaves of Strychnos usambarensis. This compound, named chrysopentamine, was identified by detailed spectroscopic methods (UV, IR, HR-ESI-MS, 1D and 2D NMR). Chrysopentamine presented an original hydroxy substitution on C-14 and an aromatization of the ring D of strychnopentamine leading to anhydronium base proper-ties and exhibited strong antiplasmodial properties (IC50 less than 1 muM).
Permalink :	http://hdl.handle.net/2268/6361

File(s) associated to this reference

Fulltext file(s):

	File	Commentary	Version	Size	Access
Restricted access	chrysopentamine.pdf	No commentary	Publisher postprint	98.2 kB	Request copy
Open access	Chrysopentamine postprintauthor.pdf	No commentary	Author postprint	127.8 kB	View/Open

All documents in ORBi are protected by a user license.