Reference : In Search of Novel Ampa Potentiators
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/6359
In Search of Novel Ampa Potentiators
English
Francotte, Pierre mailto [Université de Liège - ULg > > Chimie pharmaceutique >]
De Tullio, Pascal mailto [Université de Liège - ULg > > Chimie pharmaceutique >]
Fraikin, Pierre mailto [Université de Liège - ULg > > Chimie pharmaceutique >]
Counerotte, Stéphane mailto [Université de Liège - ULg > > Chimie pharmaceutique >]
Goffin, Eric mailto [Université de Liège - ULg > > Chimie pharmaceutique >]
Pirotte, Bernard mailto [Université de Liège - ULg > > Chimie pharmaceutique >]
2006
Recent Patents on CNS Drug Discovery
1
3
239-46
Yes
International
1574-8898
[en] Glutamate is the major excitatory neurotransmitter in the brain. Amongst ionotropic receptors responding to glutamate, the AMPA subtype has been considered as essential for the fast excitatory neurotransmission in the central nervous system and the expression and maintenance of long-term potentiation. As glutamate is known to be involved in many neurological and psychiatric disorders, AMPA receptors seem to represent interesting targets to develop therapeutic drugs. Hence, the enhancement of AMPA signals is an approach currently investigated for the management of Alzheimer's disease, schizophrenia or mood disorders. In particular, many efforts are being conducted in the development of AMPA positive allosteric modulators ("potentiators"), which alter the rate of receptor desensitization. The major chemical families developed as AMPA potentiators are aniracetam derivatives, cyclothiazide derivatives and biarylpropylsulfonamides derivatives.
http://hdl.handle.net/2268/6359

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