Article (Scientific journals)
In Search of Novel Ampa Potentiators
Francotte, Pierre; De Tullio, Pascal; Fraikin, Pierre et al.
2006In Recent Patents on CNS Drug Discovery, 1 (3), p. 239-46
Peer reviewed
 

Files


Full Text
In search of novel AMPA potentiators.pdf
Publisher postprint (2.71 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Glutamate is the major excitatory neurotransmitter in the brain. Amongst ionotropic receptors responding to glutamate, the AMPA subtype has been considered as essential for the fast excitatory neurotransmission in the central nervous system and the expression and maintenance of long-term potentiation. As glutamate is known to be involved in many neurological and psychiatric disorders, AMPA receptors seem to represent interesting targets to develop therapeutic drugs. Hence, the enhancement of AMPA signals is an approach currently investigated for the management of Alzheimer's disease, schizophrenia or mood disorders. In particular, many efforts are being conducted in the development of AMPA positive allosteric modulators ("potentiators"), which alter the rate of receptor desensitization. The major chemical families developed as AMPA potentiators are aniracetam derivatives, cyclothiazide derivatives and biarylpropylsulfonamides derivatives.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Francotte, Pierre  ;  Université de Liège - ULiège > Chimie pharmaceutique
De Tullio, Pascal ;  Université de Liège - ULiège > Chimie pharmaceutique
Fraikin, Pierre ;  Université de Liège - ULiège > Chimie pharmaceutique
Counerotte, Stéphane ;  Université de Liège - ULiège > Chimie pharmaceutique
Goffin, Eric ;  Université de Liège - ULiège > Chimie pharmaceutique
Pirotte, Bernard ;  Université de Liège - ULiège > Chimie pharmaceutique
Language :
English
Title :
In Search of Novel Ampa Potentiators
Publication date :
2006
Journal title :
Recent Patents on CNS Drug Discovery
ISSN :
1574-8898
Publisher :
Bentham Science Publishers, United Arab Emirates
Volume :
1
Issue :
3
Pages :
239-46
Peer reviewed :
Peer reviewed
Available on ORBi :
since 16 February 2009

Statistics


Number of views
105 (27 by ULiège)
Number of downloads
11 (9 by ULiège)

Scopus citations®
 
29
Scopus citations®
without self-citations
20
OpenCitations
 
22

Bibliography


Similar publications



Contact ORBi