Article (Scientific journals)
Unsuccessful Induction of Endometriosis in Female Rhesus Macaques (Macaca mulatta).
Defrère, S.; Squifflet, J.; Lousse, J. C. et al.
2008In Gynecologic and Obstetric Investigation, 66 (2), p. 84-90
Peer Reviewed verified by ORBi
 

Files


Full Text
Defrère GOI 2008.pdf
Publisher postprint (364.71 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Animal model; Endometriosis; Macaca mulatta; Primate; Rhesus monkey
Abstract :
[en] Background/Aims: The aim of this study was to induce endometriosis in female rhesus macaques (Macaca mulatta) for research purposes. Methods: Three female monkeys from 4 to 4.5 years of age underwent three consecutive attempts at endometriosis induction over an 8-month period: (i) the first attempt involved intravaginal sampling of endometrial tissue and transplantation into the intrapelvic cavity; (ii) the second entailed surgical removal of endometrium after hysterotomy and intra-abdominal placement, and (iii) the third used endometrial mucosa obtained by scraping the uterus after hysterectomy, placed in a surgical pouch created in the retrovesical space (Retzius). In each case, the pelvic cavity was closely inspected after 7, 9, and 6 weeks respectively for the presence of endometriotic lesions, and peritoneal biopsies were performed. Results: Neither macroscopic observation nor histological analysis revealed any endometriotic lesions. Conclusion: This failure to induce endometriosis in female rhesus macaques suggests that this species is not the most efficient experimental model among primates to investigate endometriosis development or treatment.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Defrère, S.
Squifflet, J.
Lousse, J. C.
Van Langendonck, A.
Gonzalez-Ramos, R.
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement
Jérôme, Christine  ;  Université de Liège - ULiège > Département de chimie (sciences) > Centre d'études et de rech. sur les macromolécules (CERM) - Chimie des macromolécules et des matériaux organiques
Delattre, Luc ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Donnez, J.
Dehoux, J. P.
Language :
English
Title :
Unsuccessful Induction of Endometriosis in Female Rhesus Macaques (Macaca mulatta).
Publication date :
April 2008
Journal title :
Gynecologic and Obstetric Investigation
ISSN :
0378-7346
eISSN :
1423-002X
Publisher :
S. Karger, Basel, Switzerland
Volume :
66
Issue :
2
Pages :
84-90
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 June 2010

Statistics


Number of views
70 (7 by ULiège)
Number of downloads
1 (1 by ULiège)

Scopus citations®
 
6
Scopus citations®
without self-citations
5
OpenCitations
 
4

Bibliography


Similar publications



Contact ORBi