Reference : Unsuccessful Induction of Endometriosis in Female Rhesus Macaques (Macaca mulatta).
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Unsuccessful Induction of Endometriosis in Female Rhesus Macaques (Macaca mulatta).
Defrère, S. [ > > ]
Squifflet, J. [ > > ]
Lousse, J. C. [ > > ]
Van Langendonck, A. [ > > ]
Gonzalez-Ramos, R. [ > > ]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement >]
Jérôme, Christine mailto [Université de Liège - ULg > Département de chimie (sciences) > Centre d'études et de rech. sur les macromolécules (CERM) - Chimie des macromolécules et des matériaux organiques >]
Delattre, Luc mailto [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
Donnez, J. [ > > ]
Dehoux, J. P. [ > > ]
Gynecologic & Obstetric Investigation
S. Karger
Yes (verified by ORBi)
[en] Animal model ; Endometriosis ; Macaca mulatta ; Primate ; Rhesus monkey
[en] Background/Aims: The aim of this study was to induce endometriosis in female rhesus macaques (Macaca mulatta) for research purposes. Methods: Three female monkeys from 4 to 4.5 years of age underwent three consecutive attempts at endometriosis induction over an 8-month period: (i) the first attempt involved intravaginal sampling of endometrial tissue and transplantation into the intrapelvic cavity; (ii) the second entailed surgical removal of endometrium after hysterotomy and intra-abdominal placement, and (iii) the third used endometrial mucosa obtained by scraping the uterus after hysterectomy, placed in a surgical pouch created in the retrovesical space (Retzius). In each case, the pelvic cavity was closely inspected after 7, 9, and 6 weeks respectively for the presence of endometriotic lesions, and peritoneal biopsies were performed. Results: Neither macroscopic observation nor histological analysis revealed any endometriotic lesions. Conclusion: This failure to induce endometriosis in female rhesus macaques suggests that this species is not the most efficient experimental model among primates to investigate endometriosis development or treatment.

File(s) associated to this reference

Fulltext file(s):

Restricted access
Defrère GOI 2008.pdfPublisher postprint356.16 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.