Reference : Distribution Of Hydrophobic Residues Is Crucial For The Fusogenic Properties Of The Ebol...

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/63520

Title :	Distribution Of Hydrophobic Residues Is Crucial For The Fusogenic Properties Of The Ebola Virus Gp2 Fusion Peptide
Language :	English
Author, co-author :	Adam, B. [> > > >]
	Lins, Laurence [Université de Liège > > Gembloux Agro-Bio Tech >]
	Stroobant, V. [> > > >]
	Thomas, Annick [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie moléc. et numér. >]
	Brasseur, Robert [Université de Liège > > Gembloux Agro-Bio Tech >]
Publication date :	2004
Journal title :	Journal of Virology
Volume :	78
Issue/season :	4
Pages :	2131-6
Audience :	International
ISSN :	0022-538X
Abstract :	[en] The lipid-destabilizing properties of the N-terminal domain of the GP2 of Ebola virus were investigated. Our results suggest that the domain of Ebola virus needed for fusion is shorter than that previously reported. The fusogenic properties of this domain are related to its oblique orientation at the lipid/water interface owing to an asymmetric distribution of the hydrophobic residues when helical.
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/63520
DOI :	10.1128/JVI.78.4.2131-2136.2004

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