Reference : Apolipoprotein L-1 Promotes Trypanosome Lysis By Forming Pores In Lysosomal Membranes
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/63492
Apolipoprotein L-1 Promotes Trypanosome Lysis By Forming Pores In Lysosomal Membranes
English
Perez-Morga, David [> > > >]
Vanhollebeke, Benoit [> > > >]
Paturiaux-Hanocq, Françoise [> > > >]
Nolan, Derek P. [> > > >]
Lins, Laurence mailto [Université de Liège > > Gembloux Agro-Bio Tech >]
Homble, Fabrice [> > > >]
Vanhamme, Luc [> > > >]
Tebabi, Patricia [> > > >]
Pays, Annette [> > > >]
Poelvoorde, Philippe [> > > >]
Jacquet, Alain [> > > >]
Brasseur, Robert mailto [Université de Liège > > Gembloux Agro-Bio Tech >]
Pays, Etienne [> > > >]
2005
Science
309
5733
469-72
Yes (verified by ORBi)
International
0036-8075
[en] Apolipoprotein L-I is the trypanolytic factor of human serum. Here we show that
this protein contains a membrane pore-forming domain functionally similar to that
of bacterial colicins, flanked by a membrane-addressing domain. In lipid bilayer
membranes, apolipoprotein L-I formed anion channels. In Trypanosoma brucei,
apolipoprotein L-I was targeted to the lysosomal membrane and triggered
depolarization of this membrane, continuous influx of chloride, and subsequent
osmotic swelling of the lysosome until the trypanosome lysed.
Researchers ; Professionals
http://hdl.handle.net/2268/63492
10.1126/science.1114566

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