Reference : The "Tilted Peptide Theory" links membrane insertion properties and fusogenicity of v...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/63273
The "Tilted Peptide Theory" links membrane insertion properties and fusogenicity of viral fusion peptides.
English
Charloteaux, Benoît [Université de Liège - ULg > > Gembloux Agro-Bio Tech >]
Lorin, Aurélien [> > > >]
Brasseur, Robert mailto [Université de Liège - ULg > > Gembloux Agro-Bio Tech >]
Lins, Laurence mailto [Université de Liège - ULg > > Gembloux Agro-Bio Tech >]
2009
Protein & Peptide Letters
Bentham Science Publishers Ltd.
16
7
718-25
Yes (verified by ORBi)
International
0929-8665
Hilversum
The Netherlands
[en] Amino Acid Sequence ; Humans ; Lipid Metabolism ; Models, Biological ; Molecular Sequence Data ; Mutation ; Peptides/chemistry/genetics/metabolism ; Viral Fusion Proteins/chemistry/genetics/metabolism ; Virus Internalization
[en] Class I fusion glycoproteins of viruses are involved in the fusion between viral envelope and cell membrane. A region located in the N-terminal domain of these glycoproteins, called the fusion peptide, is essential for fusion. Fusion peptides are able to induce by themselves in vitro membrane fusion. In this paper, we review the properties of those peptides related to their fusogenicity, in particular the correlation existing between their ability to insert obliquely in membranes and fusogenicity. This relation notably allows predicting successfully the minimal region of some fusion peptides sufficient to induce significant in vitro fusion. The notion of obliquity and fusogenicity is discussed in terms of the existing proposed mechanisms for viral fusion.
http://hdl.handle.net/2268/63273

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